Hello y'all.
I'm currently being maintained on 32mg/day (dosed twice daily) generic Buprenorphine (monotherapy, my diagnosis is "depedence" rather than "addiction", so to save money, I get the Subutex generics rather than Suboxone...) for dependence caused by treatment with high-dose loperamide for neurogenic chronic diarrhea. Note that I've been on this dosage for months, so I'm not really in the induction phase.
Luckily, I have a great doctor, so I get to try out how the buprenorphine can best help me, including dissolving and plugging it, but that's a different story altogether 8(
Usually, I only get a small and short drug-like effect when I dose, and this is as such fine. I have a full-time job (developing software) so I like to 'be sharp'.
Now, during the summer-time, I have horrible grass, oak etc. allergies. So I eat acrivastine (non-sedating histamine) 16mg + 120mg pseudoephedrine tablets three times daily.
I've noticed that this increases the drug effect of the buprenorphine vastly. My pupils, whilst on the buprenorphine, are normal size–but when throwing in the pseudoephedrine, they constrict massively, I get itchy, buzzed and even nod out somewhat. I used to study medicine (have a bachelor of medicine degree, never qualified to be an MD) so I'm quite familiar with the concept of enzyme inhibition/induction
But pseudoephedrine doesn't really affect the enzymes that the buprenorphine is metabolised by. Even IF PE was a CYP inhibitor, buprenorphine is metabolised to norbuprenorphine by a whole array of CYP's—including many that the PE doesn't touch. Also, the effect also happens if I take the allergy tablets hours after dosing the buprenorphine.
So, is there any knowledge of a direct, opioid-effect bosting effect from Pseudoephedrine on Buprenorphine? Can't find anything in the literature, but if anyone knows, it's gonna be you guys. Hope you can help.
I'm currently being maintained on 32mg/day (dosed twice daily) generic Buprenorphine (monotherapy, my diagnosis is "depedence" rather than "addiction", so to save money, I get the Subutex generics rather than Suboxone...) for dependence caused by treatment with high-dose loperamide for neurogenic chronic diarrhea. Note that I've been on this dosage for months, so I'm not really in the induction phase.
Luckily, I have a great doctor, so I get to try out how the buprenorphine can best help me, including dissolving and plugging it, but that's a different story altogether 8(
Usually, I only get a small and short drug-like effect when I dose, and this is as such fine. I have a full-time job (developing software) so I like to 'be sharp'.
Now, during the summer-time, I have horrible grass, oak etc. allergies. So I eat acrivastine (non-sedating histamine) 16mg + 120mg pseudoephedrine tablets three times daily.
I've noticed that this increases the drug effect of the buprenorphine vastly. My pupils, whilst on the buprenorphine, are normal size–but when throwing in the pseudoephedrine, they constrict massively, I get itchy, buzzed and even nod out somewhat. I used to study medicine (have a bachelor of medicine degree, never qualified to be an MD) so I'm quite familiar with the concept of enzyme inhibition/induction
But pseudoephedrine doesn't really affect the enzymes that the buprenorphine is metabolised by. Even IF PE was a CYP inhibitor, buprenorphine is metabolised to norbuprenorphine by a whole array of CYP's—including many that the PE doesn't touch. Also, the effect also happens if I take the allergy tablets hours after dosing the buprenorphine.
So, is there any knowledge of a direct, opioid-effect bosting effect from Pseudoephedrine on Buprenorphine? Can't find anything in the literature, but if anyone knows, it's gonna be you guys. Hope you can help.