Opioids Buprenorphine IV advice, please

[ansyntis]

Hi. I've been using BL forums for a long time to get all my information, and it's never failed me. Now... I'm trying to figure something out and I'm not sure where to start.

Here is my question, and my history is below:

What is the best way to dose on straight bupe via IV for euphoric effects? I just got switched to the generic subutex a week ago,, and I've been iving it for about four days now. I'm doing 4mg at a time, which I know is high... And I shot 20mg today, and 24 yesterday (over the whole day).
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How much should I be injecting, how often, what's the max,, and how long should I wait? I will try to only do a few mg tomorrow and see if it helps. But I want to use as little as I can right now so I can start getting it out if my system.

I'm an opiate addict, and I've been using for seven years. My last bout had me doing dilaudid/roxies, three to four times a day IV... I'd say about 30mg of D daily or 150mg of O daily. I switched to Loperamide and I was taking approximately 150mg a day and it was enough to curb my opiate withdrawals. I used that for five months, and started suboxone, 16mg a day. I don't know what other advice I can give... But if I should be injecting .5-1mg twice a day to get a buzz all day vs the twenty mg a day I'm taking now to get a slight two hour buzz at a time...

Thank you all in advance.

 

[hatrix]

High doses of buprenorphine are very pointless and a waste of drug. I don't have any IV experience, so I can't help you there.

But doses of buprenorphine <2mg actually have the active metabolite norbuprenorphine attaching to your opiate receptors. It's a full agonist and provides more euphoria than buprenorphine. When you dose 2mg+, buprenorphine takes over because of it's incredibly high affinity, and being only a partial agonist doesn't have as desirable effects recreationally.

I'm pretty sure IVing subutux pills is very unhealthy and rather dangerous because of all the filler contained in them. I'd recommend against using IV as an ROA. Maybe try plugging instead, as it also offers a very high BA compared to IV.

 

[ansyntis]

Okay, so my next question is... When you say less than 2mg... Are you talking about the bio available amount, or just the dose depending on roa? Ie, do you mean that I should stick to less than 2mg when iv ing, which would be approximately 6.5mg oral (@30 percent BA), or 2mg oral, which would be .6mg IV?

 

[mrflowers00]

if you're going to IV pills get some micron filters please it's much safer and don't heat the pills it will temporarily liquify the fillers/binders in the heat then when you inject it it will resolidify in your veins

 

[Fire&Water]

Many countries still use Buprenex for pain (ampules of sterile buprenorphine) but they are, and never exceed 0.2 mg's-0.3 mg's
That is less than one third of 1 mg.

Do not IV 24 mg's of subutex !!! Holy Shit

 

[down508]

I would suggest cutting small pieces off the pill. what I do is cut an 8mg pill in half, then cut that in half, then cut that quarter pill in half and do that much at a time. redose when you feel like you need it, but understand that your doses wont last as long when I.V.'d

 

[ansyntis]

Thank you for the HR information, but I'm well versed on pill preparation.

What I'm concerned about now is dosage amount and dosing times.

Generally, it looks like the consensus is approximately 1mg at a time iv d. How often do you feel that it lasts? 2-3 hours? I haven't had a shot in closer to 14 hours now. I don't feel sick, but I don't have a buzz now either.

 

[Fire&Water]

You probably have at least 16 mg's, still in your system...
and you will never achieve "a buzz" unless you can get down to a steady less than 1 mg.
And thats after you get your tolerance back down to close to zero

 

[FnX]

The thing is, as you say, you've been an opiate addict for years and you've been abusing plenty of full agonist opioids, and buprenorphine is a partial agonist at the mu-opioid receptor. For somebody who isn't used to huge amounts of daily full-agonist opioids, even 0,2mg of buprenorphine should be enough to cause pleasant effects. If you don't get the effects you're hoping for with max 2mg of buprenorphine and you feel sick/withdrawing from the low amounts which allow for more norbuprenorphine, I honestly don't think you can abuse this medication for a high and maybe you should consider using bupe to actually get off the opiates or at least start working on lowering your tolerance?

 

[hatrix]

Okay, so my next question is... When you say less than 2mg... Are you talking about the bio available amount, or just the dose depending on roa? Ie, do you mean that I should stick to less than 2mg when iv ing, which would be approximately 6.5mg oral (@30 percent BA), or 2mg oral, which would be .6mg IV?

Just because 2mg IV is EQUIVALENT to a 6.5mg oral dose (though I'm sure it's actually much higher), does not mean 6.5 is active in your system. How ever much you take is how ever much is in your system. Yes, this plays into account BA of course. If the BA of oral was only 15% and you took 6mg, you would still have <2mg in your system and norbuprenorphine would be the active metabolite at your receptors.

 

[Znegative]

It's funny because I feel like those on Subutex often inject way higher dosages than those on suboxone.

Anyway, Like everyone else is saying, when injecting buprenorphine, you need much, much less than sublingual dosages. If you want to equate a sublingual dose to its intravenous dose, multiply the SL amount by .3.

One thing to note though, when comparing IV Bupe to SL or other administrations, is that even though IV is clearly much stronger, it is also metabolized almost immediately, which makes the duration of effect feel much shorter. Because of this, I don't think you can simply say 'shooting 2 mg/ day is equal to taking 7-8mg sublingually", especially if you're doing multiple shots a day (say 4x .5mg). IME, whenever I switched from IV Bupe back to sublingual or rectal, I would only have to take one dose that was 1.5-2x stronger than my IV dose and it would last me all day (so if I was shooting 1.2 mg/day made up of 4 x 300 microgram injections, I would take about 1.5-2mg sublingually, as 1mg SL = .3mg IV).

Anyway, back to the OP's question, if you want to get stronger euphoric effects start tapering down. Aim for 1-2mg shots at a time (if you insist on using Bupe IV) for three days, so you don't shoot more than 4-8 mg a day. Try to aim to lower your daily amount to 4mg within the next week. Then lower your dosages so your doing a total of 2mg/day....this is when the effects will become more pronounced from your shots. When you get down to IV'ing a total of 1mg/day, I guarantee you will feel very apparent agonistic effects from the Bupe.

I would like to add in closing that you don't need to shoot Bupe to get high off of it, you just need to taper down to a low dose under 2mg. Also, whenever I see threads regarding IV Bupe I feel inclined to suggest that you try plugging your suboxone instead. It hits just as fast and hard, but it lasts super long so you only need to dose once daily, and the BA is still high (around 60%).

 

[Mr.Scagnattie]

If you're used to full agonists like hydromorphone, especially IV, I don't see how you could get anything really worth it at all from bupe.

In most cases, even semi-opiate tolerant people no longer can get any real euphoria from bupe, even at the proper dosages. It usually just ends in disappointment.