enoughorangejuice?
Bluelighter
- Joined
- Jan 7, 2007
- Messages
- 3,213
dukewizard1986 said:1. For the benzodiazepenes do not waste time plugging because it has no increase in bioavailability. Putting clonazepam among others under the tongue to dissolve and absorb may be a better alternative to swallowing.
2. Oxycodone works well when insufflated and it has more to do with how fast dopamine is released when snorting than the overall bioavailability. Filters in various oxy products play a big role as well. Plugging is a waste of time and Oxycontin should just be chewed.
3. For methylphenidate the nasal bioavailability is near 70%. This is often disputed because drug companies that design the drug and its analogues for children do not want to list a bioavailability for a dopamine re-uptake inhibitor that is stronger than cocaine aside from serotonin re-uptake.
4. To increase availability looking into enzymes is crucial for absorption. CYP-450 is of course crucial for many benzodiazepenes and opiates/opioids.
1. i've plugged xanax and valium and it makes them kick in MUCH quicker. within 2 minutes as opposed to 6-10 minutes when taken orally. i notice 10mg plugged valium is SLIGHTLY stronger than 10mg oral valium. IMEs that is.
2. plugging oxycodone IR , even oxycontin (brand name works best) is MUCH MUCH MUCH better than snorting oxy. much more is absorbed and you get higher and the duration lasts longer and you get much more of a rush plugging oxy than sniffing it IMEs. i just snorted 30mg roxicodone (ethex) and didn't get high. yesterday i plugged 10mg and felt waves of euphoria, etc. I'd bet that oxycodone has a higher rectal BA than oral or insuffilated.
3. ritalin/focalin is stronger than cocaine? per mg is what you mean? please post a link with a source that supports that statement.
4. For benzos the CYP3A4 is one the one you should focus on to extend duration of benzo highs and slow down the metabolization of them. Grapefruit juice and even star fruit (carambola) work on the CYP3A4 enzyme both of which potentiate benzos/opioids.