Bioavailability/Half-Life Version 2.0
Morphine: 15-40%, 20-45mg
DiaMorphine: varies, and dose dependent; Oral: - SDU Nasal:35-70%, Tmax ~15min? SDU 7.5-15mg
IV onset immediate, peak <5min
Oxycodone: mean ~50%,R 35-70%*
Tmax 1-2h duration oral/IV/Nasal: 4-8h(rectal Tmax is 2-4h, IIRC, w/ a longer duration of 8-12 hours
Methadone: Ba- Oral:40-90%, mean 70-80%~ SDU: Acute: 10-20 Chronic 5-10mg duration of action 4-12h, up to 24h Chronic(Steady state, duration is dose dependent, and Methadone itself is complex)
Primary CYP3a4, note that increasing PH enchances absorption & can increase half life.
Morphine: 15-40%, 20-45mg
DiaMorphine: varies, and dose dependent; Oral: - SDU Nasal:35-70%, Tmax ~15min? SDU 7.5-15mg
IV onset immediate, peak <5min
Oxycodone: mean ~50%,R 35-70%*
Tmax 1-2h duration oral/IV/Nasal: 4-8h(rectal Tmax is 2-4h, IIRC, w/ a longer duration of 8-12 hours
Methadone: Ba- Oral:40-90%, mean 70-80%~ SDU: Acute: 10-20 Chronic 5-10mg duration of action 4-12h, up to 24h Chronic(Steady state, duration is dose dependent, and Methadone itself is complex)
Primary CYP3a4, note that increasing PH enchances absorption & can increase half life.