Cocaine Beta + Calcium Channel Blocker?

[Pothedd]

I don't take these on a regular basis. No heart problems to speak of. It's just sometimes I get anxiety and feel like my heart is racing or going to explode.
Anyway, I have verapamil and atenolol on hand for such an occasion. I've seen that a beta-blocker combined with an adrenergic stimulant can result in periphral effects, such as dangerous hypertension.

This is where the verapamil would come in. Would taking both be a good idea to reduce cocaine-induced tachycardia and hypertension? Or would it be more wise to just take the verapamil without the atenolol?
That's if it's needed. Chances are I wouldn't require either, but I took Yohimbine earlier today and was thinking of partaking in some powder tonight.

 

[Pothedd]

Nobody has any idea? My post is about to disappear from the front page of O.D. so I had to bump it. Seriously though, does nobody know how good of an idea this is?
I've read somewhere that verapamil would be good for cocaine overdose.... Just want to know, if I need to, should I eat both, or just one?

 

[xxl]

You certainly mean preventing cocaine OD, not treating it.

Yes, beta-blockers can be lethal with coke. As to what hypertension or anti-arrhythmic are safe, who knows? At least the people who know do not seem prepared to tell. One wouldn't want to give the hundreds of millions of coke abusers in the world the impression that they can protect against heart damage by taking a particular prescription drug.

Only one thing: Dilitiazem is often added to coke as an adulterant. It could play a part in reducing the danger of heart attack. It is also a calcium channel blocker, like the drug you mention (Verapamil).

If you decide to test this combination, at least take your time, start with small amounts of coke.

One safe and proven combination is coke + diazepam, the latter also having some soothing effect on the heart. But there's the issue of benzo addiction to take into account.

 

[Pothedd]

I only did a little coke, had a couple beers.
I felt fine.
Eventually the yay wore off and I'd been drinking. After smoking dank my heart started still going fast, though I was sitting still. I started feeling off so I broke a verapamil in half and took it with an atenolol.
I'm back home safely, my heart seems to be fine. Still lit. Took melatonin hoping to sleep. I have work in the morning.

Anyway I was just asking about taking it for tachycardia. If I needed. I felt like my heart might start going fast, and I might want to take atenolol to slow it down.
But I already knew that taking a beta block would only block the beta (duh) adrenergic effects and create dangerous hypertension.
Verapamil would then lower your blood pressure that was increased (possibly dangerously) by the atenolol.

I was asking if anyone could see why this would be dangerous. So far I feel fine. Just took 5-htp too (has like 50mg of valerian root in it, next to nothing). Hoping to sleep soon.

 

[Voxide]

Never take beta blockers with coke.

 

[dokomo]

You'd be no better off with that combination. If you're going to take cocaine, do not take beta blockers.

Its still dangerous because you're blocking beta receptors and leaving alpha adrenergic stimulation unopposed. People have asked about this before, and asked about taking alpha AND beta blockers to counteract this. This is still problematic because its difficult to balance the effects, and really can only be managed effectively in a clinical setting.

The best thing to use to reduce the symptoms you mentioned are benzodiazepines.

Its also worth mentioning that you shouldn't take the combination of other stims (you mentioned yohimbe) with cocaine lightly. Many of the case studies where young (people in their late teens to early twenties) healthy having heart attacks on cocaine occurred when they had combined alcohol, cocaine and cigarettes. Alcohol greatly increases the toxic effects of cocaine and adding an additional stimulant into the mix really puts you at risk.

 

[Pothedd]

I know. The yohimbine was taken far earlier in the day, before noon. The yay was done near midnight. Yohimbine's half-life is quite short, so I'm fairly certain that it had worn off by then.
I wish I had access to benzos... I got a doctor's appointment right now. Sucks cuz I don't feel that awesome today. So tired. Slightly nauseous...
Hate alcohol...

 

[Pothedd]

So would verapamil on its own be reliable for tachycardia and hypertension?
I read somewhere that it would be a novel drug to reduce cocaine stimulation and abnormalities in the heart's rhythm...

 

[Pothedd]

Cocaethylene may be terrible for you, it may build up in the liver over the years, idk.
I just want to know if verapamil would be good to take after coke, to make your heart chill out. I read somewhere that it was, but can't remember where...

 

[dokomo]

While this might not be in the spirit of HR I wanted to point out that actually, cocaethylene hasn't been proven to be any more or less toxic to the heart than cocaine by itself. The "only" significant problem with cocaethylene is that its half life is about 2x that of cocaine, meaning an OD is more likely because, due to slower clearance rates, it builds up in your system more than straight coke.

Cocaethylene is also more toxic than cocaine

http://www.ijbs.org/User/ContentFullText.aspx?VolumeNO=2&StartPage=53&Type=pdf

Simultaneous abuse of cocaine and ethanol affects 12 million Americans annually. In combination, these substances are substantially more toxic than either drug alone.

https://secure.muhealth.org/~ed/students/articles/AcEM_8_p0211.pdf

It also carries an 18- to 25-fold increase over cocaine alone in risk for immediate death.

http://www.ncbi.nlm.nih.gov/pubmed/9243342

In addition to being just as (if not more) cardiotoxic, its exposed to cardiac tissue for a longer period of time and (unlike cocaine) is also toxic to the liver and other organs and bodily systems.

I don't find the fact that most fatal heart-attacks in healthy young people due to cocaine involved alcohol and cigarettes reveals anything particularly surprising; I mean, who on Earth does coke without drinking and smoking?

Understanding the mechanisms behind what cause heart attacks in young, healthy, non-atherosclerotic patients goes a long way in understanding why alcohol, nicotine, and other stimulants make the situation far worse.

 

[xxl]

It would be interesting to see if cocaine teetotallers, ie users who use cocaine and absolutely nothing else, fare markedly better.

P.S. Such cocaine teetotallers exist.

 

[Pothedd]

Cocaethylene is bad mmkay.
It will probably kill you, mmkay?
But is verapamil smart or not that's all I want to know???
I already am quite certain the cocaethylene is terrible, but alchol helps keep my heart rate down I guess...

 

[dokomo]

Cocaethylene is bad mmkay.
It will probably kill you, mmkay?
But is verapamil smart or not that's all I want to know???
I already am quite certain the cocaethylene is terrible, but alchol helps keep my heart rate down I guess...

I tried to explain before, but here goes -

- Don't take beta blockers AT ALL
- Verapamil should be ok to take after cocaine use to mitigate some symptoms, however benzodiazepines (or using less coke to begin with) will be much safer.

HOWEVER

You shouldn't take verapamil and alcohol together. So, it would only be ok to take verapamil after cocaine IF you haven't taken any beta blockers AND if you haven't had alcohol at all.

 

[Wizzle]

Maybe change DOC? As a stim amphetamine is cheaper and significantly less cardiotoxic

 

[Pothedd]

Thanks dokomo.
I don't really have a DOC. Meth is definitely not my favorite though. Lasts too long. I can't afford to lose weight and cocaine allows you to eat the same day lol.
I barely ever use hard drugs though. Socially and for special occasions. I usually smoke cannabis at least once a day, but sometimes I don't even do that.

Is the reason behind not drinking alcohol on a calcium channel blocker because of the risk of bradycardia ?