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Best way to take tramadol.

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It does bypass first-pass metabolism, but it will still reach the liver and be metabolised, it will just take a bit longer.

According to this, bioavailability of tramadol is 77.0% rectal, 68-72% oral (increases with repeated dosing). Wikipedia agrees :)

This is an old thread so I'm going to close it, but if you have any queries feel free to shoot me a pm (or start your own thread :) )
 
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