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Opioids Best Way to Take Oxycodone.......

J

JBRONCFAN

Greenlighter
Joined
Jan 31, 2013
Messages
13
I think the basic consensus when it comes to oxy is to just eat it. With it's almost 90% success rate surviving stomach acids and it's smooth consistency which makes it impossible it jam up your nose, eating is the way to go.

Snorted a 10/325 Perc the other day and got a NICE buzz from it, which was a surprise. Had me thinking. The obvious difference is the aceteminophen. So I crushed a 325 of pure acet. and mixed it with a few roxis.......BANG!!!! Very nice!!!!

The super smooth consistency of roxi makes it impossible for it to hang out in your nose so you can keep snorting so every snort you take sends opiods into your brain. It just dissolves quick and ends up in the back of your throat and eventually swallowed. Mixing it well with the right amount of acete allows it to act just like the Perc.

Please experiment yourself and report back.
 
Why would you ever mix apap with it purposely?
Apap severely lowers the amount of opiates making it to the brain because it coats the nasal passages and doesn't let in any opiates in certain spots. Have you tried eating the same perc?
I used to snort percs all the time but my nose would get clogged and all that apap burnt the hell out of my nose causing extreme damage to my sinuses. One day I popped one and holy shit it was like snorting two or 3 but I ibky took one I felt it so much fuller and better.
The trick isn't to mix apap that's a horrible idea but rather to snort the oxys in tiny rails every 3-5 mins until its gone so you don't get drips this goes for heroin too. Although even if it does drip down oxy has a higher B/A when eaten So its no big deal. Heroin this is more important because the oral bioavailability of heroin is crap something like 30 percent.
 
It's a SMALL amount of apap. Crush a Tylenol 325 and maybe take HALF the amount and mix it with 3 crushed 30mgs roxis. Packs up REAL nice into your nostrils and just sits there and EVERY time you give it a snort a nice blast of opioids gets sent to your brain.

Got better things to do then to post bullshit threads. Do what you will.
 
JBRONCFAN said:
It's a SMALL amount of apap. Crush a Tylenol 325 and maybe take HALF the amount and mix it with 3 crushed 30mgs roxis. Packs up REAL nice into your nostrils and just sits there and EVERY time you give it a snort a nice blast of opioids gets sent to your brain.

Got better things to do then to post bullshit threads. Do what you will.
Click to expand...

What on Earth are you on about?
 
Rybee said:
Worthy of a read covering this area:
Bioavailability-Half-life-MEGA-Thread
Oxycodone-insufflation-bioavailability-vs-oral-bioavailability

To quote Myshkin 'Eat it. Every time. Just fucking eat it'

Also, this:

I honestly don't know whether you've written it wrong or I've read it wrong but why on earth would you mix apap with it?
Click to expand...

"Just fuckin eat it".

Why? In that case, just fucking eat heroin, at high doses it's BA is actually about the same... But seriously, to dispell the many myths of oxycodone:

First off, IV oxycodone is 1.5-2x as potent as oral oxycodone(and it tends to be 2x more often than 1.5x), and, the half-life of IV oxycodone is EXACTLY THE SAME AS THE ORAL HALF-LIFE. So IV oxycodone is 1.5-2x as potent as oral, and lasts just as long. So they're is literally no advantage to oral oxycodone, when compared to IV(or even IM). Of course injecting is bad and blah blah, but if your already injecting H and dillies, IV oxy is literally superior in every way

Secondly(and this is related to the first) the oral BA of oxycodone is not "very high" as everyone claims. In reality, the oral BA is highly variable, ranging anywhere from 35-90%. The mean is somewhere between 50-70%, though it appears to be much closer to 50 than 70%.

And finally, oral is not better than intranasal. Despite what many have claimed, the oral and nasal BA's are about the same, both around 50%. However, intranasal hits much faster, with a tman of 10-20min, vs oral, which had a tmax of around 90 minutes.

So all in all, oral has no benefits, aside from simplicity. IV is much stronger, and with an identical half-life; intranasal is about the same, at worst, the BA might average a tiny bit lower, but no one would notice the slight difference, and it is compensated by the MUCH FASTEE onset. So technically, IV is the best,(though not exactly recommended!) with intranasal and oral being tied, although I think most would agree intranasal is superior.(Not me, I don't snort drugs :) )


Edit: Rybee I saw your other post, and thanks. And let me clarify I'm not being rude, it's just that they're us a lot of misinformation about oxycodone,(among other things) and I am trying to clear it up!!!
 
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Lorne??? said:
"Just fuckin eat it".

Why? In that case, just fucking eat heroin, at high doses it's BA is actually about the same... But seriously, to dispell the many myths of oxycodone:

First off, IV oxycodone is 1.5-2x as potent as oral oxycodone(and it tends to be 2x more often than 1.5x), and, the half-life of IV oxycodone is EXACTLY THE SAME AS THE ORAL HALF-LIFE. So IV oxycodone is 1.5-2x as potent as oral, and lasts just as long. So they're is literally no advantage to oral oxycodone, when compared to IV(or even IM). Of course injecting is bad and blah blah, but if your already injecting H and dillies, IV oxy is literally superior in every way

Secondly(and this is related to the first) the oral BA of oxycodone is not "very high" as everyone claims. In reality, the oral BA is highly variable, ranging anywhere from 35-90%. The mean is somewhere between 50-70%, though it appears to be much closer to 50 than 70%.

And finally, oral is not better than intranasal. Despite what many have claimed, the oral and nasal BA's are about the same, both around 50%. However, intranasal hits much faster, with a tman of 10-20min, vs oral, which had a tmax of around 90 minutes.

So all in all, oral has no benefits, aside from simplicity. IV is much stronger, and with an identical half-life; intranasal is about the same, at worst, the BA might average a tiny bit lower, but no one would notice the slight difference, and it is compensated by the MUCH FASTEE onset. So technically, IV is the best,(though not exactly recommended!) with intranasal and oral being tied, although I think most would agree intranasal is superior.(Not me, I don't snort drugs :) )


Edit: Rybee I saw your other post, and thanks. And let me clarify I'm not being rude, it's just that they're us a lot of misinformation about oxycodone,(among other things) and I am trying to clear it up!!!
Click to expand...

Obviously excluding IV (as the OP only mentioned insufflation or ingestion) you say that 'intranasal and oral being tied' but then say 'most would agree intranasal is superior.'

Then, is intranasal tied or superior to oral !?

I've always been informed that when it comes to insufflation or ingestion, there is such negligent difference that it's better to just ...'Eat it... Just fucking eat it!'

Also just for clarfication, what do you mean by 'However, intranasal hits much faster, with a tman of 10-20min, vs oral, which had a tmax of around 90 minutes.' ??

Informative post as always, though!
 
Rybee said:
Obviously excluding IV (as the OP only mentioned insufflation or ingestion) you say that 'intranasal and oral being tied' but then say 'most would agree intranasal is superior.'

Then, is intranasal tied or superior to oral !?

I've always been informed that when it comes to insufflation or ingestion, there is such negligent difference that it's better to just ...'Eat it... Just fucking eat it!'

Also just for clarfication, what do you mean by 'However, intranasal hits much faster, with a tman of 10-20min, vs oral, which had a tmax of around 90 minutes.' ??

Informative post as always, though!
Click to expand...

Sorry, a typo. I meant Tmax, as in the time it takes to reach peak plasma(and therefore peak effects). Tmax of intranasal is 10-20 minutes,vs oral Tmax, which is 1-2h.

As I said, I don't snort pills(or any drugs, for that matter.) But most people I know personally prefer intranasal oxy(though most IV now, unfortunately) and of course, I have snorted plenty of oxy, years ago before I started IV'ing. To me personally, their wasn't a big difference, though intranasal was definatly more euphoric, and much better for DT's, since it hits so much faster.

I consider them (more or less) equal, and they are equal in terms if BA(oral is likely even a little higher) but most seem to prefer intranasal, and I can see why, since I can't imagine not injecting them(on the rare occasions I get them).

But really I am just trying to defend the poor people who snort they're oxy. I mean these people have been told for years that oral is supposedly 1.5-2x as potent, which is insane. They have told than oral oxy has this amazing BA of 60-80%, and that intranasal is like 45%, but anyone who has done them knows it's not. And you have people saying "oral is basically the same as IV", again, not true. The silliest thing is people claiming rectal is comparable to IV, which still cracks me up.(for the record, rectal oxy has an average BA of around 50%, and the Tmax ranges from 2-4h)

So it's just this thing about oxy, having so many misconceptions, when it is quite possibly the most abused opioid in the us(heroin notwithstanding, though at least in my area, oxy is far more prevalent.

But yeah, it was absolutely nothing towards you, I just used your post as a jumping off point!

But the funny part? I don't even like oxy that much! I think it's overrated, and I know that it is overpriced. I have always preferred morphine, even before I tried heroin the first time...
 
Dr. Lorne, thanks for the back up......

There's actually a really cool documentary on the Frontline website that describes how insuffilated drugs absorb thru the sinuses and go directly to the brain (only substances that can cross the BBB (blood brain barrier).

People were right when it came to roxicodone not being effective or not as effective when snorted compared to eating it. No one could explain why.

Like I mentioned in my first post, my tolerance was very low at the time when I snorted a 10/325 Percocet and BANG.....was pleasantly surprised especially since it only had 10mg of oxy and I usually take two 30mg of the roxi orally. The only obvious difference was the apap. Two of the roxis are 6 of the Percs PLUS all that apap that goes with the Percs.

When I actually THOUGHT about the process of snorting the roxis I realized that they are very mushy, the slide right thru your nostrils and almost immediately down your throat. They never get the chance to stay and hangout inside your nose so you can, like you do with the Percs, snort every minute or so and each snort sends a beautiful shot of love up into your brain. It's the consistency of the roxis that is the problem, which I changed by adding a touch of apap.

So I Frankensteined two, 30mg roxis with about 175mg of apap. WAY, WAY below the amount of apap I normally would have had to consume had I snorted 6 Percs (6 x 325 = 1950mgs). Actually, they still had a bit of mush to them, I probably will add more apap next time so I can REALLY anchor them inside my nose. Maybe someone here can experiment with this?
 
Lorne??? said:
"Just fuckin eat it".

Why? In that case, just fucking eat heroin, at high doses it's BA is actually about the same... But seriously, to dispell the many myths of oxycodone:

First off, IV oxycodone is 1.5-2x as potent as oral oxycodone(and it tends to be 2x more often than 1.5x), and, the half-life of IV oxycodone is EXACTLY THE SAME AS THE ORAL HALF-LIFE. So IV oxycodone is 1.5-2x as potent as oral, and lasts just as long. So they're is literally no advantage to oral oxycodone, when compared to IV(or even IM). Of course injecting is bad and blah blah, but if your already injecting H and dillies, IV oxy is literally superior in every way

Secondly(and this is related to the first) the oral BA of oxycodone is not "very high" as everyone claims. In reality, the oral BA is highly variable, ranging anywhere from 35-90%. The mean is somewhere between 50-70%, though it appears to be much closer to 50 than 70%.

And finally, oral is not better than intranasal. Despite what many have claimed, the oral and nasal BA's are about the same, both around 50%. However, intranasal hits much faster, with a tman of 10-20min, vs oral, which had a tmax of around 90 minutes.

So all in all, oral has no benefits, aside from simplicity. IV is much stronger, and with an identical half-life; intranasal is about the same, at worst, the BA might average a tiny bit lower, but no one would notice the slight difference, and it is compensated by the MUCH FASTEE onset. So technically, IV is the best,(though not exactly recommended!) with intranasal and oral being tied, although I think most would agree intranasal is superior.(Not me, I don't snort drugs :) )


Edit: Rybee I saw your other post, and thanks. And let me clarify I'm not being rude, it's just that they're us a lot of misinformation about oxycodone,(among other things) and I am trying to clear it up!!!
Click to expand...

Of course IV is better than oral or insufflation But we wernt talking about that you mentioned oral or snorting why would we promote IV use to you if your not already IVing. But taking a percs by mouth does let you feel the med fully and has a higher B/A than snorting especially when apap is in it the apap doesn't work to your favour all that much it will take away some if any but it will give better pain relief cause apap and opiate mixed do work better than opiates alone at lower doses of each so mabye that's what your feeling too. Its also the faster rush you enjoy but me u figure waiting the extra 5 minutes is worth it to feel the while med properly and not waste any getting clogged up in my nose. Some people would rather snort it some would rather eat it it doesn't mean snorted is Better than oral.

Not saying your wrong just some people prefer different things apap doesn't increase the absorption though its makes the pills easier to conserve as you can mix it in and split then up And the apap does make for better pain relief. But its horrible on the nose and doesn't increase anything really its kinda mental I found as your snorting more powder therefore it should be Better than the other tiny rail. If you want to increase absorption then do tiny rails and let it sit up in your nasal cavities by not snorting it hard to pass it through. I've tried it though and would never mix apap purposely into oxy ever again as I found it to be pointless and my livers shot from apap.

You got your preferred route which is snorting as you probably have an addiction to the whole act of making rails and snorting them and others prefer to wait a lottle bit to feel the oxy fully and stronger after taking it orally because the B/A is higher orally apap or no apap I've felt the difference many others have too when their used to snorting percs then one day they pop one and get higher than they ever were getting snorting them. The best way is to chew those roxis up and swallow them stronger than snorting but it won't fulfill your snorting fetish which is why a lot of people just continue to snort when oral works just as good and then some.
When you take the oxys by mouth do you take them whole? You mentioned 2 oxy 30s popped don't feel as good as one perc snorted.
 
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AGAIN and very simply.......it is my OPINION that the inclusion of a very small amount of apap allows the roxi to literally stay much longer inside the nasal cavity so the user may slowly snort the drug and deliver the opioids directly to the brain.

In plain words the apap is only an anchor. You might be able to use aspirin or ibuprofen the same exact way....who knows? You might be able to crush a vitamin C pill and get the same effect.
 
JBRONCFAN said:
Like I mentioned in my first post, my tolerance was very low at the time when I snorted a 10/325 Percocet and BANG.....was pleasantly surprised especially since it only had 10mg of oxy and I usually take two 30mg of the roxi orally. The only obvious difference was the apap. Two of the roxis are 6 of the Percs PLUS all that apap that goes with the Percs.
Click to expand...
This
 
JBRONCFAN said:
AGAIN and very simply.......it is my OPINION that the inclusion of a very small amount of apap allows the roxi to literally stay much longer inside the nasal cavity so the user may slowly snort the drug and deliver the opioids directly to the brain.

In plain words the apap is only an anchor. You might be able to use aspirin or ibuprofen the same exact way....who knows? You might be able to crush a vitamin C pill and get the same effect.
Click to expand...

Now im not a doctor or anything, but I dont see how that would really make sense at all. If there is more filler clogging up your nasal membranes they will not be able to absorb the oxycodone as efficiently and while it may let you "slowly snort the drug", im not sure why you would want the effects coming on slower when you are already trying to bypass the time release in the first place.

Snorting APAP is to be avoided in my opinion
 
^^^thats what I say too and don't snort aspirin either that burns 10 times worse than apap.
Apap wreaks havoc on your sinuses its a well known fact and Apap is also so chalky that a lot goes into the lungs which isn't good. You can't mix them up good enough so the slippery oxycodone won't slide down the throat they are still serperate substances with different consistancys that arnt going to fuse together well
 
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even if some of the oxycodone goes down your throat it has a higher BA when taken orally anyway so its not like you are losing out on anything. It just travels a different path to your receptors

just dont blow your nose or spit, that might get rid of some of it
 
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Lorne??? said:
Sorry, a typo. I meant Tmax, as in the time it takes to reach peak plasma(and therefore peak effects). Tmax of intranasal is 10-20 minutes,vs oral Tmax, which is 1-2h.
Click to expand...
Aaah makes sense now, thanks!


Lorne??? said:
As I said, I don't snort pills(or any drugs, for that matter.) But most people I know personally prefer intranasal oxy(though most IV now, unfortunately) and of course, I have snorted plenty of oxy, years ago before I started IV'ing. To me personally, their wasn't a big difference, though intranasal was definatly more euphoric, and much better for DT's, since it hits so much faster.

I consider them (more or less) equal, and they are equal in terms if BA(oral is likely even a little higher) but most seem to prefer intranasal, and I can see why, since I can't imagine not injecting them(on the rare occasions I get them).

But really I am just trying to defend the poor people who snort they're oxy. I mean these people have been told for years that oral is supposedly 1.5-2x as potent, which is insane. They have told than oral oxy has this amazing BA of 60-80%, and that intranasal is like 45%, but anyone who has done them knows it's not. And you have people saying "oral is basically the same as IV", again, not true. The silliest thing is people claiming rectal is comparable to IV, which still cracks me up.(for the record, rectal oxy has an average BA of around 50%, and the Tmax ranges from 2-4h)

So it's just this thing about oxy, having so many misconceptions, when it is quite possibly the most abused opioid in the us(heroin notwithstanding, though at least in my area, oxy is far more prevalent.

But yeah, it was absolutely nothing towards you, I just used your post as a jumping off point!

But the funny part? I don't even like oxy that much! I think it's overrated, and I know that it is overpriced. I have always preferred morphine, even before I tried heroin the first time...
Click to expand...

Well considering what you've said, I've just given insufflation a try, so I can actually tell for myself instead of what others say! Was only ~15 min ago so will give an update in this thread, and compare it to ingesting it at the same dose.

Not a massive opiate user any more though. I've got degenerative disc disease so get chronic spinal pain which I used to control with Fentanyl patches... until that went very wrong. Then just stuck with MS Contin for day-to-day use and Oxycodone for breakthrough pain. I ended up with really bad hyperanalgesia from the opiates which weren't controlling the pain anymore so I took the hard decision of ditching them for Dosulepin, to be better off in the long run. Still get awful breakthrough pain some times which I use either Oramorph or Oxycodone for, but I've really cut down a hell of a lot. Only really use them as a last resort when I'm in tears. I'm going to be in a state of life-long chronic pain, so my attitude towards opiate use had to change and I had to cut it out!

Anyway, as said, just given it a go. Tried 30mg in two rails of 15mg up each nostril. Found it to be quite a lot of powder and wouldn't like to snort any more than 30mg in future... would probably divide it up into 4x10mg rails with a bit of a gap in between if I went to 40mg. Don't think any more than 40mg insufflated would be practical though. Mild burn for 5 minutes but absolutely fine after.

Anyway, 20 min in now, not feeling much yet but sure it will kick in sooner or later. FYI the brand was from the UK, though doubt it makes any difference, was capsules, not tablets so made for a smooth insufflation.

OP, I will see what it's like and compare it with ingestion tomorrow so you can hear my thoughts on it.
 
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In the future when snorting do 5mg rails so it stays up in the nose and dissolves In the nasal cavity.
 
Couple questions:

1) When you snort, does any amount go into lungs? Tried it, never felt as though, but cant really imagine not..
2) Per previous post, if oral really does have such a wide swing of BA, then what causes that? Stomach conditions (PH)? Food / liquid used to consume? Is there a preferred liquid that creates an ideal environment for high oral BA?

Thanks!
 
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