Low to therapeutic dose of xanax and maybe a klonopin in the mix so the comedown is smoother + Strong dose of opiates, i prefer oxycodone or morphine personally, but obviously hydrocodone works too + 50mg-100mg of hydroxyzine or benadryl to potentiate opiates (don't let yourself pass out) + A lot of weed. Strong Indicas compliment the body high from the opiates perfectly, but Sativas will increase your mental euphoria a lot. If you have trouble staying awake, caffeine always helps out, but too much can kill your buzz IMO.
My personal combo. 4mg-6mg of xanax + 40-60mg of oxycodone ( I usually pop perc 10s because OC's are becoming super rare and OP's are garbage) or 60-90 mg of morphine. or Opanas + 50mg hydroxyzine + Medical/Hydroponic weed. Regs/mids don't compare unless your thc tolerance is low to none and you have no taste for good weed.