i was wondering the same thing, i used to take them to come down, because when i crash i crash hard. . . xanax helps me get to sleep, sleep hard, and it lets all my muscles relax, so i find it to be a good combo, but i am no expert. . .someone once told me that was how elvis died, not from E and xanax, but just a combo of extreme uppers and etreme downers. . . so i really don't know, hope someone here has a knowledgeable answer, cause i'd like to know too!