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benzodiazepine + opiates

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benzofan

Greenlighter
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Jul 23, 2010
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anyone could explain (scientifically of course, we are in the advanced drug discussion 8))

how benzodiazepine impacts in the brain someone already under opiates effects

e.g a man has take 50mg of hydrocodone what will be the effect if he adds one hour later 30 mg of valium ?

Increase teh effect of the opiates (i think certainly not)
Give a stimulating effect (psychoanaleptic effect ?)

other way...

If someone could clarify that point with accuracy it would be great

(maybe if possible a scientist, biologist,....)
 
The two together will significantly add to the "sedative" effect you'll experience. Each in itself can be somewhat sedating, but together, it's more like 4-5x. Just be careful. Over sedation is the # 1 reason people OD or die from too much drugs. They take so much, they just go to sleep and never wake up. The synergistic effect is especially important because many with high tolerances seek more and more med, or start combining drugs / meds, and that's when the shit hits the fan.

The doses you're describing should be fine, but expected to be sedated. You'll certainly sleep well, that's for sure.

Good luck.
 
The patient Mr. Man would be experiencing the effects of synthetic opioid agonism, being sedation, analgesia, nausea etc.

The addition of an benzodiazepine (which acts by allosterically modulating GABA receptors increasing the likelihood of GABA binding and hence inhibitory effects) would also produce sedation and loss of motor control although through different pathways.

The combination of both drugs has significant potential to cause fatal respiratory depression. As 'Experienced PMer' mentions this is the primary cause of death during drug overdoses.

It will not increase the effects of opiates per se.
It will not produce a stimulatory effect

The doses you describe may be within safe limits individually but require great caution in combination.
 
Moving to OD, as the neurochemical details of any possible interaction aren't yet known, so we must approach the combination as additive in key ways.

ebola
 
benzofan said:
(maybe if possible a scientist, biologist,....)
Click to expand...

You see the medical degree on my wall, right? ;)

I don't think you'll be able to know dick about the credentials anyone who replies has, unless you are willing to believe what they say.

Anyways, benzos and opiates will typically produce synergy. There are extraneous examples, like if you were to have a paradoxical effect to diazepam, but for the most part I would not expect stimulation.
 
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