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Benzo-Derivative that mimics ethanol

Holy_cow

Holy_cow

Bluelighter
Joined
Nov 29, 2007
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171
I remember having read about a Benzo-derivative that mimics the effects of ethanol. Does anyone remember more than that or could possibly lead me to the corresponding publication?
 
QH-ii-066 replicates some of the effects of alcohol, such as sedation and ataxia, but does not increase appetite, as this effect seems to be produced by the α1 subtype of GABAA rather than α5.[6]

Get this to market! I need a benzo that doesn't make me want to eat everything in my house!
 
It would be an interesting compound to taste and the structure would have you believe that it's only a short step from diazepam. Well, it is, but using some pretty funky chemicals and LOW yields...
 
That's the first benzo I've ever seen that doesn't have a halogen anywhere on it. That's incredibly interesting. I didn't think that any non-halogonated (barring the nitro-benzos) were active.
 
I just can't believe that people like ethanol enough to be seriously excited about making a benzo analog with mostly identical effects, but I guess that's just me.
 
It was the QH-II-66 what I had in mind. Thanks to all who helped me figure it out!
 
haribo1 said:
It would be an interesting compound to taste and the structure would have you believe that it's only a short step from diazepam. Well, it is, but using some pretty funky chemicals and LOW yields...
Click to expand...

Pagoclone is relatively cost effective to make. Might end up being some sort of fun, and I don't think it would fall under the analogue act in the US because of the novel structure.
 
^Many thanks for the lead. I had never heard of pagoclone. Now, reading about it, I see that Mr. David Nutt suggested that it would be an alternative to alcohol. I
Know that the stuff is used to help people with bad stutters so I'm slightly dubious about what it's really like. Still, partial agonist, good idea!

Pagoclone - Seems interesting...
 
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^Actually, Pagoclone hits the a2 & a3 subreceptors, but QH-II-66 targets the a5 and to a lesser extent the a1 subreceptor types. Well, a1 is where the sleepiness and amnesia come from. a5 is also hit by the normal benzos.

If only we could find agonist that act on a single subreceptor so we could find the balance that is the 'nicist'.
 
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