all amps, release dopamine and serotonin in the brain causing the high. eventually, you deplete ur brain of these chemicals and now are just binging to give ur brain artificial dopamine and serotonin, you need to sleep and replenish with food water and vitamins. the more u choose to get high after a nights sleep, the less euphoric it will be and more of a tolerance developed..treat it like MDMA. I think using it once every 2 weeks is fine..or for me..if I do it every 3 days..im fine..no binging, staying up all; night..just dosing and effect wise im good