Banyu compounds - new opiate class

[haribo1]

Another new class of opiate agonists, more insights into the receptor shape.

Notice how similar they are to bezitramide or even etonitazine?

 

[Ham-milton]

yep. I missed that last line and was going to say so. 15 and 16 remind me a bit of ketobemidone.

 

[fastandbulbous]

Some of those look frighteningly simple structures to synth if they are of the same sort of potency as the likes of the nitazenes

 

[Smyth]

The basic theme seems strikingly similar to one of the compounds C6H6 pulled out of one of Lednicer's ebooks.

 

[MattPsy]

Ok, so i've forgotten the whole deal with these ORL1/NOP agonists, are these the ones that don't produce tolerance?
I certainly hope so : > .

 

[morphiquet]

orl1-ANTagonists can attenuate the development of opioid tolerance to a certain degree.

i somehow don't get this thread. 8)
where are the values for compounds 14-17 and these others? besides, most of them are µ-antagonists and those which aren't are incredible weak agonists. ??? could you please clear up the sense of the thread to me?
( maybe I'm just stupid )