Misc BA of Cesamet/Nabilone orally or intranasally?

[THE_REAL_OBLIVION]

I can't find an answer anywhere and I hate to be one to make a "Can you snort X drug?" thread but there's so little info around for nabilone, Cesamet™ so I'll bite the bullet and ask here. One of my Cesamet gelcaps got pierced accidentally and now i have collected all the powder inside of it.

It seems like it is indeed the pure powder, this is exactly 1mg of powder. What one can do with this other than eating it ? I'm pretty old compared to more here but I remember when I was young and dumb and we would make jokes about snorting pure thc and the like...I guess this comes as close as I ever will to maybe do it once for real. Any ideas and links?

 

[sekio]

There's no point in administering the drug via insufflation; most of it won't get absorbed.
Rationale: nabilone is a solid at and slightly above room temperature, so it will remain solid. it's also poorly soluble in water, which makes it hard to absorb into blood.

One could smoke it or vapourise it, or plug it as an oil suspension I'd guess. I'd be most apt to smoke it.

 

[THE_REAL_OBLIVION]

There's no point in administering the drug via insufflation; most of it won't get absorbed.
Rationale: nabilone is a solid at and slightly above room temperature, so it will remain solid. it's also poorly soluble in water, which makes it hard to absorb into blood.

One could smoke it or vapourise it, or plug it as an oil suspension I'd guess. I'd be most apt to smoke it.

Yeah I was thinking of smoking it by sandwiching some powder between some weed and hot knive that (poor man's vapourizer). I just wonder if the high would be drastically stronger from smoking it like most cannabinoids...

 

[tricomb]

What is the point? You think you'd get better potency or BA or something? With THC, oral ingestion (lower BA accounted for) allows for 11x more potent active metabolites to be formed compared to the inhaled (smoked/vaporized) ROA.

TL;DR cannabinioids work incredibly via the oral route and you needn't bother with other ROAs, (you could plug it if you enjoy plugging, to each his own. certainly nothing wrong with the rectal route from this observers point of view.... but I'm not sure whether it would be much more advantageous than the oral ROA.)

P.S. I've talked to patients who rectally take cannabinoids (usually for chemo-nausea) in a lipid suspension and report great degrees of success.

getting off topic: The rectal ROA is a GREAT alternative to the IV ROA especially outside of a hospital / professional environment, because pretty much anyone can be trained to administer drugs via the rectal ROA. I'd imagine from a novice's caregiver's standpoint, it's a lot easier to give a microenema or insert a suppository than working with IV gear, solution, proper HR, and of course hitting a vein, I think we can all agree...

Great example: Diazepam Rectal Gel (DiaSTAT) for epilepsy. I mean, can you imagine trying to IV someone who's having a prolonged (5+ minutes) epileptic seizure, a medical emergency by every definition? I sure as hell would be reaching for the rectal diazepam, not the IV ativan... The needle could easily break off if you managed to get it inside the vein of a seizing patient.... again, the rectal ROA to the rescue lol but that's just my $0.02

 

[THE_REAL_OBLIVION]

What is the point? You think you'd get better potency or BA or something? With THC, oral ingestion (lower BA accounted for) allows for 11x more potent active metabolites to be formed compared to the inhaled (smoked/vaporized) ROA.

TL;DR cannabinioids work incredibly via the oral route and you needn't bother with other ROAs, (you could plug it if you enjoy plugging, to each his own. certainly nothing wrong with the rectal route from this observers point of view.... but I'm not sure whether it would be much more advantageous than the oral ROA.)

P.S. I've talked to patients who rectally take cannabinoids (usually for chemo-nausea) in a lipid suspension and report great degrees of success.

getting off topic: The rectal ROA is a GREAT alternative to the IV ROA especially outside of a hospital / professional environment, because pretty much anyone can be trained to administer drugs via the rectal ROA. I'd imagine from a novice's caregiver's standpoint, it's a lot easier to give a microenema or insert a suppository than working with IV gear, solution, proper HR, and of course hitting a vein, I think we can all agree...

Great example: Diazepam Rectal Gel (DiaSTAT) for epilepsy. I mean, can you imagine trying to IV someone who's having a prolonged (5+ minutes) epileptic seizure, a medical emergency by every definition? I sure as hell would be reaching for the rectal diazepam, not the IV ativan... The needle could easily break off if you managed to get it inside the vein of a seizing patient.... again, the rectal ROA to the rescue lol but that's just my $0.02

Ah..here comes the mandatory "plug it" guy/response, sorry i don't have a oral syringe here, i have no interest in going to the pharmacy just to obtain one, people smoke their rc cannabinoids, I'm wondering if anybody out there ever smoked nabilone powder. I already ate some, I got a huge jar here so I can experiment with it alright.

 

[tricomb]

Did you not read my post? I condoned the oral route and could care less which route you pick, the rectal ROA discussion was off topic as I stated and was in response to Sekio's post bringing it up in the first place.

Don't apologize to me man if you can acquire nabilone but not a simple oral syringe, that's allllll goooood.

I'm interested to hear how the inhaled ROA (smoked/vaporized) works, let us know.

 

[THE_REAL_OBLIVION]

I haven't done it yet I will continue my research and make use of university vpn with all the extra research one can do on those (it's kidna like canadian pubmed). I need to know other things like is nabilone a full or partial agonist of cb1 and cb2 receptors. If its a partial agonist like actual weed and not a full agonist like all those nauseating untested cannabinoids I might end up trying it very much.

 

[Kapitan.Crunk]

^bump...Just to clear this up..dont smoke this shit guys..it tastes like ass, horrible taste! also it doesn't provide any effect when smoked..mind you i just used a piece of folded aluminum foil but still i cant imagine any better effects another way of smoking?..

if your gunna take this stuff just eat it, trust me..a friend get large bottles of these to supplement his medical cannabis, and has given me tons of them over the years. Currently I has about 20 of these blue&white capsules of 1mg naboline/cesamet. and the only way they will be ingested will be orally i can assure you that.
Also in my opinion, Cesametseems to have little recreational value. only once could it be said that a buzz of any kind was had. yet it was a good buzz at least 10-15mg so 10-15capsuls were ingested, aprox.2-3hr until effects were felt. and i took up into a laughing fit for some amount of time & continued to buzz until sleep occurred.

So i would say, if you have access to decent quantities of this substance and can get it for free or next to nothing then definitely give it a try. If not and someone tries to sell this stuff to you, pass on it cuz its no worth your time...get some real chronic and lite up, its a much better choice over naboline/cesamet.