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  • Trip Reports Moderator: Cheshire_Kat

Awake 61 hours moving - Stims, Nootropics, Diet and Antipsychotics

tweex

tweex

Bluelighter
Joined
Jul 10, 2013
Messages
652
Location
On the tweek again. Drinkin' county prune!
My house looked like something off an episode of hoarders.

Looked being the operative word, my lease just ended.

If ever there was a time I needed to be awake constantly and fully productive, this was it.

The actual details of what I did were quite boring, mostly boxing up and moving a couple metric tonnes of various possessions including my personal machine shop, cleaning the house, and repairing some stuff.

The interesting strategy is how I did it.

Obviously the first 12 hours weren't much a challenge, and required no special medicating. Beyond that, I cycled stimulants, supplements and nootropics in the following way:
+12:00 300mg Adrafinil, 30mg 2-FMA, 3 Ensure protein shakes
+15:00 10mg Nicotine, 3mg Guanfacine, 40mg Lurasidone
+18:00 10mg D-Methamphetamine, 20mg PQQ, 5mg Methylene Blue, 6g Piracetam, 3g Choline Bitartate, 2g Niacinamide, 50g Isomaltulose
+22:00 300mg Adrafinil, 30mg 2-FMA, 3 Ensure protein shakes
+25:00 10mg Nicotine, 3mg Guanfacine, 40mg Lurasidone
+28:00 10mg D-Methamphetamine, 20mg PQQ, 5mg Methylene Blue, 6g Piracetam, 3g Choline Bitartate, 2g Niacinamide, 50g Isomaltulose
+32:00 300mg Adrafinil, 30mg 2-FMA, 3 Ensure protein shakes
+35:00 10mg Nicotine, 3mg Guanfacine, 40mg Lurasidone
+38:00 10mg D-Methamphetamine, 20mg PQQ, 5mg Methylene Blue, 6g Piracetam, 3g Choline Bitartate, 2g Niacinamide, 50g Isomaltulose
+42:00 300mg Adrafinil, 30mg 2-FMA, 3 Ensure protein shakes
+45:00 10mg Nicotine, 3mg Guanfacine, 40mg Lurasidone
+48:00 10mg D-Methamphetamine, 20mg PQQ, 5mg Methylene Blue, 6g Piracetam, 3g Choline Bitartate, 2g Niacinamide, 50g Isomaltulose
+52:00 300mg Adrafinil, 30mg 2-FMA, 3 Ensure protein shakes
+55:00 10mg Nicotine, 3mg Guanfacine, 40mg Lurasidone
+61:00 150mg Trazodone, 6mg Melatonin, 100mg Diphenhydramine, 2mg Clonazepam

And there it was. 61 straight hours of amazing productivity, no psychosis, and watery blue poop. Not something I can say I want to do at all often, but at least I know I'm capable of it.
 
NeighborhoodThreat said:
Just wondering, why the trazodone at the end? Surely melatonin, diphenhydramine and clonazepam would be enough to knock you out after 61 hours? 2-FMA, adrafinil and d-methamphetamine is a serious stimulant combination too.

Also, have you read this in relation to mixing methylene blue with drugs?
Click to expand...

Believe it or not, I still wasn't remotely sleepy until the trazodone kicked in. My serious stimulant combination was doing its job well ;)

The doses at which Methylene Blue has significant MAO inhibition (and are used for treating conditions like methemoglobinemia) are far higher than what I was on.
 
in case you didn't notice: your use is problematic my friend!
regular/long term use of stimulants fucks with your head without you even noticing it...
take care of yourself!
 
Holy shitballs! I've been awake 36 hours myself (on 4-FA and etizolam), and I must say...that's quite a combination! Props on getting your place clean though. As long as it doesn't become a regular thing I guess it's no harm/no foul.
 
^Actually not a bad idea. If you haven't already, you should submit this report to Erowid as well.

tweex said:
Believe it or not, I still wasn't remotely sleepy until the trazodone kicked in. My serious stimulant combination was doing its job well ;)

The doses at which Methylene Blue has significant MAO inhibition (and are used for treating conditions like methemoglobinemia) are far higher than what I was on.
Click to expand...

Interesting. So if the doses of methylene blue you're taking are too low to have MAO inhibition, whats the point in taking methylene blue at those doses?
 
Here is a paper on methylene blue and MAO inhibition. It inhibits both MAO A and B, but there is a large difference in the concentrations necessary to achieve significant inhibition, with MAO A being inhibited at much lower (nanomolar) concentrations than B.

I'm not sure how to translate doses per os into molar concentrations in the blood or brain, that sort of biology stuff is anathema to a lot of chemistry students I know. I'm certainly interested to learn how such conversions of total dose to concentration in the blood plasma – taking bioavailability of the specified ROA into account and acknowledging that it will be a function that varies over time – but it is definitely super complicated due to all of the various feedback/feedforward effects, all the various metabolic enzymes, whether the stomach is empty of full, pH of the stomach and small intestines (assuming it is in fact absorbed through the intestinal wall), etc., so I can see why a lot of my fellow students would balk at the idea of something so far from the generally mechanistic world of chemistry.

---

Anyway, now to on to for pseudo-report (last paragraph of this post explains the pseudo- prefix) itself.

I feel the need to ask how you developed this regimen. This reminds me of the reefer-madness-esque fearmongering in the late nineties and early naughts about 'pill parties', an entirely false concept where 'kids' in their early teens would just take a bunch of random prescription bottles from their parents' medicine cabinets, dump them in a bag, and then take turns reaching in and eating handfuls of this mixed bag of drugs, pun intended, with not a care as to what specifically was in the bag or in their repeated handfuls.

We have antipsychotics, nootropics, atypical stimulants 'wakefulness-promotions agents' like adrafinil, vitamins, enzyme cofactors, methamphetamine, a disaccharide, an alpha-2a adrenergic agonist... I think that's it, have I missed anything? Oops, yeah, the methylene blue, which at these doses I theorize is intended as a neuroprotective agent and nootropic combo-chemical, even though the dosages are way high, as 60 ug is supposed to serve to produce nootropism.

Oops again, forgot the nicotine. How were you administering this nicotine? And are you sure you got the doses right? 0.5 to 1 mg/kg can kill a man, 30 to 60 mg roughly, you took 50 mg. True, it was spread out over some time though, but those are still high doses if it is taken all at once (not sure of the delivery method/ROA).

The niacinamide totals eight grams, and it is possible that infrequently doses of >3 grams can be harmful.

I guess I and others here are just a bit skeptical of the reasoning that lead to all this being used. I think you'd find people a lot more receptive if you were perhaps to take each chemical and briefly explain the reasoning for taking it as an addendum after the chronological part of the report. That way we could understand your reasoning, and also that would make this fit a bit better here in the trip reports forum, since there's a dearth of subjective experience or even overall impressions of this combination and its effects over time.
 
shit i'd do something like that no problem - well so long as the supps and nootropics were safe to combo with amphetamines. I hate trazodone though, seroquel would be my go to for killing a 61 binge along with copious amounts of gabaergics.

ever had to move quickly and had stims around?

re: the nicotine, if you have a tolerance, 50mg of pure nicotone and amphetamines would be a non-issue. I don't see any reason to doubt this report unless one of the combos is actually unsafe. I've done plenty of stim cleanings and multiday binges without psychosis ensuing, mostly by eating properly and staying hydrated and sleeping whenever possible.

OP: nice fucking report. btw it has recently been shown that it is far more effective to take melatonin about 5-6 hours before you sleep and at a dosage lower than 1mg. And good call on the ensure shakes, fucking love that shit when i'm spun lol.
 
^^ I didn't doubt the report, I just asked if the dosage for the nicotine was in fact 10 milligrams.

That sort of question is as much to do with ROA as it is with total dose. Ten milligrams all at once will be stronger than the same dose spread out over many hours in the form of ~2 mg of the stuff per cigarette. So I'm curious whether that's what was meant (five cigs, or three or four good cigs that are properly strong), or if it were taken all at once, and if all at once, how did it get into the body, and whether of not it had a specific purpose within the multidrug dosing regimen other than potentially fulfilling the OP's addiction, should he be a cigarette smoked like myself.

I'd also kinda have to take issue with it being a good report. I think it's a good *post*, but probably more appropriate to another forum, probably OD, since it isn't really a trip report per se. On the other hand it could be turned into a trip report so as to fit into this forum very easily. I suggest that instead of adding subjective impressions of what all this actually felt like and how that feeling changed over time (or in addition to that information), the OP add a bit after the chronological section where each compound that was ingested is named, and the reasoning for its inclusion in the stack/regimen is given. He could also perhaps add some more information in addition to the reason for its inclusion, such as whether or not he felt it fulfilled its specific job in the stack, and what aspect of his consciousness did it alter (and how it was altered) if applicable (ie this wouldn't apply to the cofactor, for example).

Just my opinion and two cents. I lean towards the more detailed, long-form reports as far as preference, others may disagree, and that's cool.

I'm not knocking the original post at all, or at least I don't intend to do so, I'm just of the mind that it belongs in OD unless the OP wishes to add more subjective impressions, which I would definitely prefer to moving the thread because I'd be curious to hear about how the sum total of all this – definitely an unusual or at least uncommon combination – ultimately felt (ie adrafinil-type 'wakefulness agents' aren't commonly combined with traditional stims like meth as far as I know).

---

BTW as far as those ensure shakes, I would urge everybody who uses that type of thing to stay nutritionally sound during drug binges (stims for you perhaps, heroin for me) that they try the Naked Juice protein zone smoothies, especially the mango protein zone. Seriously fucking manna from heaven in a bottle, I drink them all the time and the first time I had one while tripping I had to pause halfway through drinking it before resuming and finishing the bottle to give my brain a minute's rest – the gustatory pleasure was unsustainably intense!

Their other smoothies are fucking dope too, but even amongst these uniformly awesome and delicious drink the mango protein zone so totally surpasses all else!
 
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^yeah my friend uses that stuff - is it the same stuff that tastes like orange peels?

I personally liked the report, as it was so neat and concise, perfectly laid out by a tweaker lol.

Subjectively there's nothing to report but yeah the reasoning behind using such a regimen would be interesting.

it's not a detailed account of his experience, it's beauty is in its simplicity - sorry i've been awake for 38 hours lol.
 
As to the nicotine, yes the doses are quite high. They were administered as e-cigarette fluid in gelatin capsules, and thus the dose was absorbed incompletely and fairly slowly. Smoking 10mg of nicotine would probably have had me "proper fucked".

As to why I ended up with the particular agents I did, the reasoning is really quite simple: they combined to make me extremely functional for a long period with few side effects. Was I randomly "throwing in" pills? Hell no, everything had a reason.

Here is a bit more detailed reasoning...

D-meth and 2-FMA being the primary long acting stimulants. Why not just d-meth? Too euphoric to do proper productive work. Why not just 2-FMA? Not euphoric enough to keep me doing mindnumbing work for that long.

Why Adrafinil? It metabolizes to Modafinil, and potentiates amphetamines wakefulness promoting properties. Lets me get away with lower amphetamine doses.

Why Nicotine orally with Guanfacine? Guanfacine is a hypotensive agent that plays well with adrenergic stimulants, and has pro-cognitive properties in and of itself. Nicotine adds that extra edge to keep you focused.

Why the hell take Lurasidone, an antipsychotic? To counteract stimulant psychosis, duh! It in fact works quite well. Completely removes the paranoid tweaker side of things and seeing shit that isn't there, even out to 61 hours.

Isomaltulose? Ensure? Simply nutrition that is easy to keep down when you aren't hungry. The former is a very slowly broken down sugar, and lets you keep "buzzing around" for an extended period compared to other sugars.

Piracetam? Choline Bitartate? Taken together, they really help clear up that slightly dissociated sluggish feeling from lack of sleep

Niacinamide? Really good anxiolytic at high doses, granted I wouldn't take that much every day, but there is no solid evidence it causes any harm.

Methylene Blue, PQQ? Neuroprotective agents. The reasoning should be obvious in a scenario like this for damage mitigation.

What makes this trip report the most interesting is frankly that it was rather boring. The entire time I felt relatively energized and motivated without being tweaked out.

An extreme case of moving such as this represents one of the most demanding tasks shy of prolonged combat for stimulant use. I recently drove for 24 hours, and saw no need for anything beyond a single 600mg dose of Adrafinil with 400mg of Caffeine and 80mg of Propranolol.
 
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