Benzos Ativan to snort?

[snmfmy]

So being straight alp, its very easy to miscalculate the dose and take too much, which is undoubtedly what happened with my friend and I. I doubt it had a low bioavailability, but that seems to not matter so much when you are insufflating an extremely potent benzo like that, and not exactly being responsible about it.



I've been using xanax for a very long time, I know what the effects are like I would be very surprised if it wasn't alp and I didn't notice. The only other thing I would potentially humour it being is a different benzo, in which case... what does it matter? All benzos with a couple rare exceptions (like midazolam) are also not water soluble. So if they worked, I don't really get what point that proves.

I mean I can't imagine what other than a benzo, would give a benzo like affect that wouldn't be distinguishable to a long term user. I would have noticed ghb from the taste. If it was something like phenibut, it wouldn't have had the same blackout effect. If it was some kind of barbituate, I mean, those are pretty rare these days, and are ( if memory serves) also more expensive for that reason, also making it not make sense from a business perspective.

It could have easily been laced with a fentanyl analog or other unknown opiate adulterants.

Midazolam (versed) Is the only traditional benzodiazepine that forms water soluble salts. It should be noted that climazolam and loprazolam (both also imidazo based benzodiazepines) are water soluble.

Fosazepam, a derivative of diazepam, is water soluble.

Flurazepam is HIGHLY water soluble. If powder was snorted the dose could have easily caused sedation that lasted multiple days, because it has a half-life of between 47 and 100 hours.

Unlike Xanax, which has a half-life of 12 hours.

Now I could sit here and search through all of the new research, chemical benzodiazepines, and the new I think they're 1,5 benzodiazepines

Chemistry is chemistry, Xanax is not soluble in water. In fact, it's so poorly soluble, this is part of the Xanax monograph @fda.gov:

"Alprazolam is a white crystalline powder, which is soluble in methanol or ethanol but which has no appreciable solubility in water at physiological pH."

https://www.google.com/url?sa=t&source=web&rct=j&opi=89978449&url=https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/018276s045lbl.pdf&ved=2ahUKEwjZ4q2FzaCEAxVj4skDHcsyCu8QFnoECBMQBg&usg=AOvVaw17Q8xsxy4bC66PiZIz6WlM

Which means if you snorted it up your nose, it will not dissolve, NO MATTER HOW MUCH YOU WISH IT WOULD.

I can't tell you exactly what it was that your friend snorted. I can tell you what it wasn't. It wasn't Xanax. Or at least whatever caused him to be knocked out wasn't Xanax.

Any effect from Xanax that was in that powder that your friends snorted would have come from the Xanax dripping down his throat into his stomach.

At physiological pH (for our purposes that means between 5.5 and 8.5 which includes your blood which is somewhere around 7.4, saliva which is somewhere between 6.2 and 7.6, and snot which is normally between 5.5 and 6.5, but it can go all the way up to 8 when you have allergies. Obviously the stomach has a pH as low as one but we're not talking about eating Xanax) Xanax can literally not dissolve in water, that's why it's taken orally so that it goes into your stomach.

Just like boiling water will not seep into grits any faster from one kitchen to another, there is no way that Xanax is going to dissolve in your nasal passages and your sinuses and pass through your mucous membranes.

 

[snmfmy]

So being straight alp, its very easy to miscalculate the dose and take too much, which is undoubtedly what happened with my friend and I. I doubt it had a low bioavailability, but that seems to not matter so much when you are insufflating an extremely potent benzo like that, and not exactly being responsible about it.



I've been using xanax for a very long time, I know what the effects are like I would be very surprised if it wasn't alp and I didn't notice. The only other thing I would potentially humour it being is a different benzo, in which case... what does it matter? All benzos with a couple rare exceptions (like midazolam) are also not water soluble. So if they worked, I don't really get what point that proves.

I mean I can't imagine what other than a benzo, would give a benzo like affect that wouldn't be distinguishable to a long term user. I would have noticed ghb from the taste. If it was something like phenibut, it wouldn't have had the same blackout effect. If it was some kind of barbituate, I mean, those are pretty rare these days, and are ( if memory serves) also more expensive for that reason, also making it not make sense from a business perspective.

In my first reply to this post, I gave you a very detailed explanation of why you can't snort Xanax.

Because I really like figuring things out I spent. I don't know an hour and a half searching all over the web and I found:
Alprazolam-triazolobenzophenone derivative:

Alprazolam triazolobenzophenone - Wikipedia

en.m.wikipedia.org

So apparently, UPJohn Pharma developed a water soluble pro drug of Xanax in the 1980s by jamming the triazolobenzophenone group onto alprazolam, which makes it convert to Xanax at a neutral pH, meaning it turns into Xanax once it gets into your blood.

It was never really marketed and now it is an unscheduled research chemical that has been seized since 2014.

It is Not Xanax and it is very dangerous to snort powder that is a water soluble pro drug of Xanax, considering the potency of Xanax. Obviously it is ill-advised because your friend passed out for however long. If the dose was a little larger it could have been fatal.

I feel very confident that is the compound that your friend snorted.

As they say, Play stupid games when stupid prizes, fuck around and find out.

 

[Parabolan]

I used to snort benzos when I was younger, it's a waste of benzo.

 

[jp_12]

I hear what you're saying man and I totally understand what you mean. I'm no doctor or chemist, so my knowledge is at the level of a layperson, but maybe this will make sense. I understand that in chemistry, different substances are often labelled as being soluble in x y or z at x y or z Mg per Ml of volume. Some things are soluble in water, while other things are only soluble in Alcohol or Methanol or what have you.

While mucous in the nose is definitely not just water, it's water based with other organic solids floating around in it. Benzodiazepines are usually soluble in other vehicles, like Alcohol for instance, but almost all are not soluble in water, meaning the transport of the drug through the mucous membrane is never going to be efficient if it happens at all.

I'm not discounting anyone's experience, as I know many people who swear by snorting Benzodiazepines. It is my belief though that there is an excitement that they get from that route of administration that is often already ingrained. Also, anything that is not absorbed by the sinuses is typically going to end up going down the throat in a matter of minutes, so effects are going to be apparent regardless of whether the ROA actually works. It's my belief that this is why people attach themselves to this, but I'm not discounting anyone's experiences.

This. Especially addicts. We want that little dragon to possibly appear. Snorting always seems to give that possibly rather than oral or sub. You are wise

 

[jp_12]

I get the 1mg white bars of ativan ( not the tiny ones that dissolve quick for sublingual) does anyone crush the bars and do them sublingual? I always just take them down the hatch. Any experiences having the drug work faster for that mellow feel?

 

[Keif' Richards]

Hey @jp_12 in my experience, sublingual dosing is nothing to write home about relative to oral dosing. It is typically faster. Let's say you take a tablet with a relatively empty stomach and it takes ~20 minutes to feel the first effects and ~30 minutes until you're feeling it. I would say sublingual dosing can be 75% the time of oral dosing, meaning ~15 minutes until your first twinges and so on.

You're correct that reducing the pill to a powder will lead to a faster onset. I'm totally shooting from the hip here, but I feel it's safe to say a powder will shave ~5 minutes off either of these routes of administration.

I know my legacy on these forums is going to largely entail my dedication to rectal administration of drugs. I've come to terms with that. With that said, rectal administration is generally as fast or faster than even sublingual administration. In my travels, it seems that the folks who are really averse to this practice have their reasons, while those who actually try it almost always rate it highly.

Back in the day, I did this with all of the various Benzodiazepines using just water as the vehicle in the syringe. I'm not sure exactly how that works differently than the sinuses, but it does.

 

[fairnymph]

I know benzos arnt water soluble, but mucus isn’t water either….has anyone crushed up a Xanax and blown a giant snot rocket on the powder to see if it dissolves ? Cause it sure seems like snorting works to some degree

Placebo.

 

[Opana313]

Snorting Ativan or half of a kpin has always worked pretty well for me. It definitely is a fixation of the route. But yes effects will kick in much quicker but yeah if you blow a whole bar of Xanax or even one blue football, you will have an irritated nose while trying to get your buzz/relief(do you remember the little red flakes in the 1mg footballs? Was meant to deter this ROA, AND OH BOY YOU REALLY GOING TO BE PLUGGED UP)all stuffy/running not fun!(This is why I usually pop/sublingual a few and then break off a quarter piece for the nose ROA, and everytime no fail, all anxiety and bs MELTS away very quickly kinda feels like the first time). But you can only get away with this a few times/rare, because eventually you are just fucking up your nose. My right nostril is perma fried

I usually shadow box a bit to open nasal up but yeah it's my stupid habit(thanks to my roa of roxi)and hear me when I say it does work, but also hear this..DON'T DO IT! I regret it now!!!!

 

[jp_12]

Hey @jp_12 in my experience, sublingual dosing is nothing to write home about relative to oral dosing. It is typically faster. Let's say you take a tablet with a relatively empty stomach and it takes ~20 minutes to feel the first effects and ~30 minutes until you're feeling it. I would say sublingual dosing can be 75% the time of oral dosing, meaning ~15 minutes until your first twinges and so on.

You're correct that reducing the pill to a powder will lead to a faster onset. I'm totally shooting from the hip here, but I feel it's safe to say a powder will shave ~5 minutes off either of these routes of administration.

I know my legacy on these forums is going to largely entail my dedication to rectal administration of drugs. I've come to terms with that. With that said, rectal administration is generally as fast or faster than even sublingual administration. In my travels, it seems that the folks who are really averse to this practice have their reasons, while those who actually try it almost always rate it highly.

Back in the day, I did this with all of the various Benzodiazepines using just water as the vehicle in the syringe. I'm not sure exactly how that works differently than the sinuses, but

Thanks for the reply ....
I've done it all. Would get pik lines and do very unsafe shit with.
So I recently have been off booze for over a year, have a dependency to dillys and benzos.
I've never found any enjoyment or use snorting benzos. ...
I got stir crazy, not drinking after 15 years will do it. So I tried 4 mg of dill with 1mg of ativan. And ya man it made me feel good, euphoria was there, nothing like iv but good, and the calmness too. I'm very experienced with opiods especially hydromorphone and ativan but this combo actually works snorting. My only fear posting is naive users trying it. That's not my intention.
Again thanks for sharing man!!