RCs Arguement for Mephedrone

[monstanoodle]

I've only tried it once and that was just a small dab orally of it before a gig.
Completely tooka way the feeling I had of being too fucked up on Booze, slight euphoria and a good amount of energy.
But I'd wholeheartedly say that this is compound that isn't good for the mind and body as a whole.
Please be careful - Start small and then work your way up the next day or, more preferably, a few days later

 

[activity111]

what about the blue limbs and deaths? thats what people pay attention to when it comes to RCs. the number of deaths and the side effects. in this casr the side effects being severy vasoconstriction

i agree
my fingertips look reddish and my palm is blotchy
its not severe but its still there ... and its been +12h since i did last dose
binged it too much over the course of a week ... it looks like the sideeffects are only starting to get noticed now

 

[Lady Codone]

From what I've read/heard, the biggest risks aren't brain related so much as heart/vascular. Lots of things can cause brain damage when they're used compulsively (alcohol, MDMA, coke, amphetamines, benzos for example). The key would be to use sparingly or not at all.

 

[Cface]

Compared to (moderate-high dose) MDMA, meth, and even coke comedowns, mephedrone doesn't even have one [even at high doses], it just brings you back down to normal and wanting more.

And i agree with OP, if you think Mephedrone feels anything like your run-of-the-mill stimulant, you were given something else as i can binge on mephedrone all night and sit in the same spot not doing a damn thing.

I don't think any of us are in the position to say just how neurotoxic 4-mmc really is. But generally speaking, any stimulant you take will have some damaging effects to (at least) your serotonin and dopamine, i suppose the real question is how toxic it really is and compare to other stims. You can't base the toxicity on color, smell, texture, and corrosive characteristics.

One major concern i have about this particular substance is cardiotoxicity. It seems like it's worse than (good clean) cocaine from my experience just by the way it affects my heart, breathing, muscles, blood pressure/circulation. Though it may not be 4-mmc itself, but a metabolite of 4-mmc from liver processing...

Edit:
On a subjective note, I would compare mephedrone to MDMA... it's the closest "mainstream" drug to give a description. However, MDMA still has vastly more powerful and, seemingly, less dangerous side-effects. I prefer mephedrone over mdma only because the high from MDMA seems so "pushy" to me. Mephedrone seems to make me think i'm more in control of what's going on. However, i hate mephedrone for it's cardiovascular side-effects and coke-like moorish personality... as well as it's short-lived high.

 

[Amberthefrog]

It feels really dirty to me, now you can say my subjective experience of it is meaningless in defining it's toxicity, and in many ways it is. One thing I did notice though was that I could feel the vasoconstriction in my limbs on the comedown, the same happens if I drink more than 6 or so units of ethanol within a couple of hours, whilst on amphetamine. Only mephedrone feels worse, a lot worse.

Stimulants are generally very, very kind to me in terms of comedowns and day after effects (normally I can sleep 6 hours after taking MDMA and wake up feeling refreshed and in a better than normal mood the next day - he same is true for methylone (provided I don't redose more than once) and butylone - I'm also comedown free with regards to amphetamine, provided I don't miss more than one nights sleep). The first couple of time I took mephedrone, no comedown, sleep fine, no after effects. Since then though it keeps me awake and gives me the very unpleasant feeling of vasoconstricion and puts me in a bad mood on the comedown phase. Then again, this doesn't neseccarily give me any warning bells besides the vaso affect - the other stimulants I've tried which gave me comedowns were methamphetamine and MDPV, from what I've read, MDPV is about as un-neurotoxic as these sort of drugs get.

In terms of the actual experience, it can feel very good but there are things I rate much higher. For a good night out I would take MDMA, methylone, butylone or 7.5-12.5 mg of 2c-b over 4-MMC any day.

 

[F.U.B.A.R.]

Why no sources for RCs?

If you want to quote the "arguments for mephedrone" please do. Just don't link a site that sells it.

This I don't understand. I can see the need to not post sources for illegal substances, but for RCs (particularly the ones which haven't yet been banned), surely THE best method of harm reduction would be to advise people of the most reliable & trustworthy vendors? I realise you don't want the forum saturated with basically 'drug adverts' but where suppliers are operating within the law why not have a thread dedicated to personal recommendations from Bluelighters? This would prevent vendors from joining just to promote themselves and their wares.

 

[scottd420]

Methamphetamine is neurotoxic because of its serotonin release. Same exact reason MDMA is neurotoxic.

Well man, they are much, much different in my opinion. It isn't the exact same reason; the mechanism is different, but yes they do involve serotonin.
With MDMA it is believed that serotonin is dumped out of the vesicles and by the time the high is over most of the serotonin has been broken down by monoamineoxidase enzyme. Dopamine is more robust and doesn't clear as quickly since not as much was expelled into the synapses of the neuron. When there is no extracellular serotonin for the transporter proteins to re-uptake it starts selecting dopamine. When this happens dopamine is drawn into serotonin storage vesicles causing oxidative stress on the cell.

That's one believed and studied idea of MDMA toxicity.

Now, if you would kindly take two minutes and clear me up on how methamphetamine neurotoxicity works I'd really appreciate it.