Pharmacology Are ultra long-acting drugs possible?

[TheLightBringer]

I found some extremely long duration drugs while I was combing the literature.

Solmssen, Ulrich V. (1945). "Synthetic Estrogens and the Relation Between their Structure and their Activity.". Chemical Reviews. 37 (3): 481–598. doi:10.1021/cr60118a004.

Forward to triphenylethylene derivatives (page 542) and read for yourself.

I cant access it but I assume its about hormones? Nandrolone ”lasts” a really long time as well, even without being bound to an ester it has metabolites that supress the HPTA for up to 18 months

 

[red22]

I cant access it

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The Big & Dandy Long Acting Psychedelics Thread

 

[4DQSAR]

I think @Skorpio said it all.

The only thing I can add is that apparently someone synthesized the monohalomethyl derivatives of DOM. All were extremely active but all but the monofluoromethyl homologue (weakest of the series) were also alkylating agents. Long ago in some pointless thread on what exactly the most potent rather than what was the most desirable, FAB mentioned them and I think he regrets it, given that safety is a distant second to profit these days...