Are there any herbs, nootropics or medications that are antagonists?

[paranoia_]

Are there any herbs, nootropics or medications that are antagonists becides antipsychotics?

 

[Swerlz]

antagonists of what receptor?

 

[paranoia_]

any

 

[BurnOneDown]

You should make topics requesting more specific information. Questions this vague are usually best answered through your own research.

 

[Beenhead]

Yes there are, many

 

[panic in paradise]

http://www.jungcircle.com/schiznatural.htm

 

[immad]

Yes, alsem is. Thujone is a gaba antagonist.

 

[ebola?]

okay...why are you interested in whether these things antagonize any receptor?

 

[panic in paradise]

D2 antagonists make me cooookey.

like coooookey crisps, but not as sweet.

 

[yasu]

DXM is an NMDA antagonist

 

[MurphyClox]

Why not try typing "recreational antagonist" in Google?!
My first hit was this: http://en.wikipedia.org/wiki/NMDA_receptor_antagonist

And there are mentioned: Ketamine, PCP, DXM. Just some examples. None of them is a "antipsychotic".
Some nightshade-alkaloids are antagonists, too (M1-AcCh-receptor inhibition).

The question is far away from being meaningful. Sorry, but that's the truth.

Murph

 

[LuxEtVeritas]

^ about as far as ya get truth be told....

 

[grue]

hahahaha

 

[MurphyClox]

^ about as far as ya get truth be told....

???

 

[LuxEtVeritas]

^ referring to your reply:

The question is far away from being meaningful. Sorry, but that's the truth.

 

[Ham-milton]

here's a much better question: are there any endogenous ligands that are partial agonists?

 

[LuxEtVeritas]

Anandamide, an endogenous cannabinoid, inhibits calcium currents as a partial agonist in N18 neuroblastoma cells and at CB1

Endogenous γ-L-glutamylglutamate is a partial agonist at the N-methyl-D-aspartate receptors in cultured cerebellar granule cells

also other types:
Virodhamine
Endogenous cannabinoid receptor mixed agonist/antagonist found in higher concentrations peripherally than anandamide. Partial agonist/antagonist at CB1 and full agonist at CB2 (EC50 values are 1.9 and 1.4 μM, with 61% and 100% efficacy compared to anandamide for CB1 and CB2 receptors respectively). Induces hypothermia in vivo.

AgRP, physiological role of an inverse agonist (Agouti Related Protein)

Over the last decade, the ability to detect agonist-independent signal transduction by G protein-coupled receptors has in turn resulted in the detection and study of ligands able to block this activity. Such ligands are generically described as inverse agonists. Considerable attention has recently been devoted to the presence and roles of endogenous antagonist/inverse agonists and the concept that inverse agonists may have specific therapeutic benefits compared with neutral antagonists.

 

[Ham-milton]

sweet, that's supeer interesting!

 

[Hah]

hi,

"The vascular effects of gramine on resistance vessels were evaluated, in particular as regards the 5-hydroxytryptamine (5-HT) system. We compared the action of gramine with that of ketanserin, a 5-HT (2A) antagonist; both compounds induced concentration-dependent relaxation in precontracted arterial rings. Also, the 5-HT concentration-effect curve shifted to the right in the presence of gramine, like ketanserin. These results suggest that gramine is a vasorelaxing agent acting mainly by antagonism at 5-HT (2A) receptors."

http://www.ncbi.nlm.nih.gov/pubmed/15095157

 

[tadfish]

that is that deprnyl and that smart drug ummm forget its name but works alot on dopamine. alot of drugs for parkinsons and brain degeneration are helpful.
u should get some piracetam, choline, b-vits, hydergina, just get into smart drug website and forums
so far this thread is useless