I'll admit I don't know jack about presses but unless you plan on making 10+mgs pills(please for the love of God don't)I doubt it. Even if the pros could press pure single mgs or even several mgs, the pills would be next to microscopic(exaggeration..but still) and would rain death down upon us polydrug abusers. I assume you know what a single mili of alprazolam looks like since you asked. If you're handling pure diazapines without a lab grade mg scale then volumetrically dosing is the only way to go.