mmmm.....i dont know about that but it will take most of the positive effects of mdma away if an ssri is taken b4....and if you take an ssri on the regular you need to stop dayz b4 depending on the ssri's 1/2 life,atleast 4-6 dayz imo. you do still get some vision changes if your on an ssri and take mdma but pupils wont be blown and youll be pist. SSRIs protect neuro damage if takin within 3-4 hours of takin E.....noticable positive changes from ssris can take a month or so but when you pop just 1 it blocks reuptake and prevents any confused dopamine or u.f.o's from trying to up take where they shouldnt be took causing damage of neurons and also help to prevent releasing more happy brain chems when the peak is done