Opioids anyone heard of "orphines"?

[RUC4]

they are a "scary" new opiate i've heard. here is something i read about them. what do you guys think? anyone tried them? trip reports?

orphines: the new deadly opioid
article summary:

• The drugs are 10 times more dangerous than fentanyl. They are showing up in street drugs in the South and the Midwest, and will most likely spread to other regions.
• A class of synthetic drugs called orphines is throwing a new wrench into the ever-evolving opioid crisis in the United States. These drugs have tenfold the potency of fentanyl and have led to numerous overdose deaths in 2026. Experts say removing them from the streets, or even identifying them, could be extremely difficult.
• Orphines are generally considered to be at least “10 times more powerful than fentanyl, even in quantities no greater than a few sand-size grains,” said the Times. Like fentanyl, orphines can be “lethal with stunning speed, with victims slumping over abruptly, respiration shutting down, chest walls rigid.” Naloxone, a drug that reverses the effects of opioids, is effective against orphine, but “numerous doses may be required, many more than the one or two doses typically needed for fentanyl.”

 

[4DQSAR]

List of orphine opioids - Wikipedia

en.wikipedia.org

Forgive my linking to Wikipedia but it's accurate enough for you needs, I hope.

Things like brorpine can be synthesized from two commercially avaiable precursors in one step. It seems most are now rather more 'the peas and carrots' i.e. they seem to turn up as active cuts in misrepresented drugs that have rarely been sold as what they ARE.

There was some self-professed 'expert' on Reddit who banged on about how cyclorphine was amazedballs wihout ever asking why? In every other class of opioid where an NH or N-CH3 is replaced with a 2-cyanoethyl moiety you see two patterns. Almost every time the result was a far more potent 'analgesic' but as it turned out that increase potency was because the ligand isn't subtype selective with most of that analgesia due to DOR (pro-vonvulsant) and KOR (dysphoric) affiniry i.e. is so potent because it acts on ALL classes of the opate receptor... oh and in every single case it was found that the 2-Cyanonethyl homologue 'did not substitute for morphine in animal models'. Now to ME that would have been a 'clue'.

We KNOW it's possible to design extremely euphoric opioids and we KNOW it's possbile to produce extermely potent opioids.... Just not at the same time.

My hypothesis is that the subjective euphoria is because ligands rapidly bind but have a short 'receptor occupany time' so the binding-unbinding is what produces euphoria. So to 'catch a buzz' from fentanyl one has to go VERY close to the toxic dose just to force two identical molecules to compee for the same receptor.

It seems low affinity super-agonists are in their own quiet way as risky as high-affinity super-agonists with the AWS being out of all proportion to the desired effects. tianeptine, tepentaol and 7-OHM are all super-agonists. Problem is, no dose of methadone will stop the AWS and buprenorphine, forget it. But kids will be kids so each was initially viewed as amazing then quickly people found out about the 'zero trap'?

But seriously. I've met distributors and the very BEST you can expect is total inferrerence towards the end user beyond not too many deaths (potentially bringing heat) BUT at worst, these people ENJOY 'playing god' Hurting people because it's easy for them...

So while will never tell them how to live their lives, I just want everyone on BL to at least make informed decisions.

The 'mystery powder game' does rather demonstrate survivorship bias in a VERY direct way. People can't login and post 'took X at 11AM, died 11.35AM - would try again at lower dose'. Each loss is the story of a life and how brutally so many are cut short.