Anyone else think...? (2ce)

[FractalStructure]

...That 2ce seems like it might be a bit toxic, or at least have some pretty long lasting effects? All the LSD in the world never seemed to have such lasting visuals, and now that its been months since I've done it last they have faded, but when I did 2ce on a weekly basis or so I would get some crazy post-trip visuals and lasting effects, more so than any other psych I've tried, including 2c-t-2. I always figured 2ce must have been safe because 2cb is considered pretty safe, and the only difference is an ethyl group instead of bromo... obviously this is a research chemical but does anyone here have any idea of whether 2ce is safe or toxic? (or somewhere in between? As of now I'm assuming its prolly about as toxic as mdma just to be safe, even though its prolly less toxic in reality, better to be cautious)

Maybe this is a subjective matter with no real evidence but if anyone has any kind of input, it would be appreciated, as I'm trying to figure out whether to embrace 2ce (I do really like the experience, its a nice alternative to 4-aco-dmt and lsd, and I've always found it fun) or whether to stay away from it.

Either way no more weekly tripping for me..

EDIT: by "alternative" I dont mean substitute, I just meant its nice to take a phen besides mdma (dont roll anymore lately), I like the 2c's, mesc and the hallucinogenic phenethylamines

 

[solistus]

I went through a period of frequent 2C-I and 2C-E use (multiple times a week for a month or two). I did notice long-lasting effects (big doses of 2CE last as long as acid or longer for me) and higher doses of -E make me pretty nauseous, but I haven't noticed anything resembling HPPD or lingering health effects. I still use them occasionally (on a low dose of -E tonight, in fact), and any aftereffects are gone for me within a couple days.

At any rate, it's always best to be cautious, especially with RCs, but AFAIK there's no empirical evidence that 2C-E is toxic. Its unpleasant side effects on the gut are most likely due to its 5HT2B activity. As far as I understand both MDMA and 2Cs, I'm pretty sure the oxidation issues that make MDMA neurotoxic would not apply as 2Cs don't deplete serotonin and lead to oxidized dopamine binding with those receptors. My personal use hasn't given me any reason to believe it's more toxic than 2ci, at least.

You may want to research some of the other 2Cs if you're having overly intense and/or lingering effects from 2CE but want a 2C-like experience without those issues. I haven't tried any beyond -I and -E so I can't help you much there - probably stay away from the 2C-Ts if you're looking to avoid bodyload and toxicity concerns.

 

[any major dude]

2c-e is thought to be pretty safe. People have taken +100mgs and been more or less ok, but there is no data on long term effects. It could potentially cause some free radical formation because its quite similar to monamines, but this can be negated with an anti-oxidant supplement. I've done a lot of various phens & trypts (as well as a few other things ) and I've done 2c-e the most. Haven't really had any long term issue with it (or any psychedelic) at all, but YMMV

 

[Chicago66]

"I abused a drug for weeks and now I'm having negative effects"

i don't know whether or not it's toxic, but i do know that when you overdo something, it's usually bad for you.

 

[I like all cereals]

I went through a period of frequent 2C-I and 2C-E use (multiple times a week for a month or two). I did notice long-lasting effects (big doses of 2CE last as long as acid or longer for me) and higher doses of -E make me pretty nauseous, but I haven't noticed anything resembling HPPD or lingering health effects. I still use them occasionally (on a low dose of -E tonight, in fact), and any aftereffects are gone for me within a couple days.

A few friends and I insufflated a very large dose of 2C-E. I have minor HPPD, and random flashes of light in my field of vision. I also got sick when I indulged in amphetamines.(I have since quit all drugs besides psychs, the occasional beer, and marijuana) I used to rail large doses of amphets before school all the time, about a month after my first 2C-E trip I did some adderall, and for some reason I got hellishly nauseated, same exact feeling I had while on 2C-E. So, a few weeks later I tried to do adderall again, and the result was identical. I convinced myself that the 2C-E had effected my bodies sensitivity, not only to phenethylamines, but also amphetamines.(due to their similarity in some actions, and chemical structure)

Could just be in my head, but I believe it's plausible.

 

[porkstock]

i just looked up (again) the 5ht2b receptor on wikipedia (which is the receptor most activated by 2ce as well as 2ct2, TMA, and psilocin http://www.plosone.org/article/info:doi/10.1371/journal.pone.0009019) and the cardiovascular effects sound kinda sketchy. i was expecting it to say something about expression of the 5ht2b receptor in the gut somewhere to explain the nausea associated with those 4 chems.

got anything, solistus?

 

[Xorkoth]

Actually I find 2C-E's body effect to me highly psychosomatic. When I first began experimenting with it, I had some extremely heavy and toxic-feeling experiences. But as I got more comfortable with it and myself, it began to feel very smooth and light and actually distinctly MORE healthy with less impact on the body than any other 2C-X except maybe 2C-D.

I should note that I nearly always take 2C-E (and all 2C-Xs) rectally now. I find that rectal dosing with them drastically reduces the bodyload and eliminates entirely any potential nausea, as the chemical never reaches the stomach).

 

[porkstock]

i have found the opposite - the more i take 2ce the worse it makes my body feel. but that could have everything to do with THINKING it is doing that

i've considered dosing rectally, but haven't most due to convenience. i also am afraid it will burn much like snorting, and can be more dangerous

 

[Xorkoth]

Actually it doesn't burn much at all, surprisingly. I put the dose in a gel cap and just insert. It's really quite easy. The dose is about the same as you would use for snorting. I find the effects to be much more quality than the effects from snorting though, much smoother. It's really quite an effective ROA.

 

[LSDMDMA&AMP]

on the issue of snorting, i nearly had a bad trip the 2nd time i snorted 2C-E. i had a capsule, unknown dose, snorted half the one night, i think i was up all night, then snorted the remaining half or so the night after and i was freaking out from the pain. and i felt braindead the day after, much moarso than even ridiculous amounts of amphetamine do.