Depersonalization disorder
Naltrexone is sometimes used in the treatment of depersonalization disorder. While studies have suggested it is less effective than naloxone for treating depersonalization, naloxone is impractical for daily use because it must be injected intravenously. A 2005 naltrexone study demonstrated an average of 30% reduction of depersonalization symptoms, as measured by 3 validated dissociation scales.[30] Most of the efforts in studying naltrexone for depersonalization thus far have been directed by Dr. Daphne Simeon at the Mount Sinai School of Medicine.