After a looooong break from any drugs, from July-October I rolled once a month. The last six months I rolled a minimum of twice/month. Sometimes weekly, sometimes two or three days together.
I did have some times where the days after I felt more anxious/uncomfortable. And the day after I'm usually tired, although often in a pleasant refreshed kind of way.
I still find just about each experience to be amazing and insightful, although I do not find it worth using multiple days in a row.
My mental health is much better now than before I started rolling. Not saying that this is because of MDMA, but it certainly hasn't hindered my growth.