masumune
Bluelighter
I take 100 mg zoloft daily and I want to get some suboxone , is there anything I should know before getting a few strips?
Any negative interactions between suboxone and sertraline?
- Thread starter masumune
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masumune
Bluelighter
Thanks man.
tackyspiral
Bluelighter
no interactions i was prescribed both for a while
Captain.Heroin
Bluelight Crew
In my opinion, you'l have a worse time trying to come off of Zoloft than you would Suboxone.
There could be interactions that could be unique to yourself that other people here aren't experiencing. Suboxone and Zoloft have very unique pharmacological profiles. Buprenorphine is a μ-opioid partial agonist, buprenorphine is also a κ-opioid antagonist (which expands the anti-anxiety profile of the drug), and buprenorphine is also a δ-opioid antagonist. Buprenorphine's main active metabolite, norbuprenorphine, is actually a full μ-opioid agonist, a full δ-opioid agonist, as well as a κ-opioid partial agonist.
Buprenorphine and norbuprenorphine also have an effect at the ORL-1 receptors; but I won't get into that.
However, as I have illustrated here, buprenorphine itself has varying degrees of effects at different dosages, as the different proportions of buprenorphine to norbuprenorphine will yield different results on the receptors (too much buprenorphine will prevent norbuprenorphine from working, but a sweet spot dosage of buprenorphine will be high enough to get full effects but not too high so as to leave plenty of open receptors for norbuprenorphine).
I believe when you get the sweet spot of buprenorphine, the δ/κ effects balance out with only slight κ antagonism (which reduces anxiety), while partially and fully activating the μ-opioid in an optimal fashoin.
There could be interactions that could be unique to yourself that other people here aren't experiencing. Suboxone and Zoloft have very unique pharmacological profiles. Buprenorphine is a μ-opioid partial agonist, buprenorphine is also a κ-opioid antagonist (which expands the anti-anxiety profile of the drug), and buprenorphine is also a δ-opioid antagonist. Buprenorphine's main active metabolite, norbuprenorphine, is actually a full μ-opioid agonist, a full δ-opioid agonist, as well as a κ-opioid partial agonist.
Buprenorphine and norbuprenorphine also have an effect at the ORL-1 receptors; but I won't get into that.
However, as I have illustrated here, buprenorphine itself has varying degrees of effects at different dosages, as the different proportions of buprenorphine to norbuprenorphine will yield different results on the receptors (too much buprenorphine will prevent norbuprenorphine from working, but a sweet spot dosage of buprenorphine will be high enough to get full effects but not too high so as to leave plenty of open receptors for norbuprenorphine).
I believe when you get the sweet spot of buprenorphine, the δ/κ effects balance out with only slight κ antagonism (which reduces anxiety), while partially and fully activating the μ-opioid in an optimal fashoin.