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Benzos Any legal medicine for anxiety?

Pythagoras said:
enlighten us?
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I have some GABA pills and although it could be placebo, they do work as an adjunct to other downers.
There are GABA receptors everywhere in the body, so saying that GABA pills don't work because they don't cross the BBB is an invalid statement: they certainly don't work on the brain but they do work on the muscles, for instance. Even if they are kind of weak, I agree with that.
 
drugssexandmusic said:
GABA [gamma-Aminobutyric acid] is good for sleep and keeping you feeling calm. It acts on the same receptors as benzodiazepine's.
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No!

gamma-Aminobutyric acid (GABA) can not cross the BBB, and therefore it does not act on the same receptors as do the benzodiazepines, whose receptors are located beyond the BBB, which GABA cannot cross.

Please correct me if I am mistaken, but I believe that what I'm saying is the truth. Unless there are distributions of GABA receptors in the visceral and peripheral organs that I'm unaware of, but even then, GABA wouldn't bind to 'gaba' receptors. GABA is an amino acid neurotransmitter, and not a synthetic chemical.

~ vaya
 
drugssexandmusic said:
GABA [gamma-Aminobutyric acid] is good for sleep and keeping you feeling calm. It acts on the same receptors as benzodiazepine's.
Click to expand...

No!

gamma-Aminobutyric acid (GABA) can not cross the BBB, and therefore it does not act on the same receptors as do the benzodiazepines, whose receptors are located beyond the BBB, which GABA cannot cross.

Please correct me if I am mistaken, but I believe that what I'm saying is the truth. Unless there are distributions of GABA receptors in the visceral and peripheral organs that I'm unaware of, but even then, GABA wouldn't bind to 'gaba' receptors. GABA is an amino acid neurotransmitter released in seminal vesicles by presynaptic neurons. It is not a synthetic chemical.

Go with another poster's suggestion: Phenibut is a wonderful material when used sensibly!

~ vaya
 
You could maybe try St. Johns Wort, which is available at most pharmacies. You could also maybe try buspirone, which is a commonly prescribed non-narcotic anxiety medication.
 
BIGsherm7272 said:
You could maybe try St. Johns Wort, which is available at most pharmacies. You could also maybe try buspirone, which is a commonly prescribed non-narcotic anxiety medication.
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A 1970's study showed moderate efficacy above placebo with St. John's Wort.

A meta-study conducted in 2001 showed no differences between the control groups given SJW vs. placebo.

You can try it if you'd like, just thought I'd throw that in there.

~ vaya
 
What other drugs are you prescribed? I am taking a small dose of Abilify, and in addition to my Klonopin I am prescribed Benztropine, which kills the restlessness and added anxiety that the Abilify causes. It is not a scheduled drug and has no abuse potential.

Another drug which I saw already mentioned, is Buspar, which works like an antidepressant as it builds up in your system. I've heard mixed things about this one though, I've heard complaints of it being too mild, especially when combined with a typical, nonnarcotic anti-anxiety medication.
 
Cannabis is legal and OTC in some places (dispensaries) and can help with anxiety in small doses (mainly some indica strains). If the dose is controlled many people can function fine on it, especially if is a indica/sativa hybrid).

Don't take St. John's Wort. There's not really much evidence of it's effectiveness in treating anxiety (also see the study mentioned above) and it interacts with too many other medications which can be dangerous if you need to take a medication that doesn't mix well with it for some reason.

Also, GABA does cross the BBB in small but significant amounts if taken in sufficient doses.
 
Last edited:
Yer I just read somewhere that GABA doesn't cross the blood brain barrier.
So I guess my experience with it was the placebo effect, but someone on here said that all the receptors are not just in the brain.

I think they are, for it to relax your muscles it would have to interact with the receptors in your brain with in turn send an signal down to your muscles to relax.

I don't know about Kratom though when I did it. It was a semi-trippy experience not opiate like at all. You should try Valerian root like others have said or maybe Wild lettuce.
 
drugssexandmusic said:
Yer I just read somewhere that GABA doesn't cross the blood brain barrier.
So I guess my experience with it was the placebo effect, but someone on here said that all the receptors are not just in the brain.
Click to expand...

This is true; GABA receptors are distributed widely throughout the human body. This does not mean, however, that once a GABA supplement you've taken, once it has binded to a GABA receptor on your leg (for example), will cross the BBB; it will not, being that it's an amino acid.

~ vaya
 
Teaching and researching

leftwing said:
do a little research yourself
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I am more than happy to do research, its what I do all day, but I see nothing wrong with asking someone who makes a statement about Gaba receptors being spread across the body to fill us in a bit, I had a genuine interest, as did he/she so the question was neutral. If every statement on BL was met with 'do your own research' I think it would be a rather dull place.:\:\

PAX
 
Taurine, Magnesium Citrate, Phenibut 250 - 500 mg capsules work well. Some people use Theanine but it just makes me sleepy.
 
agreed with kava...but don't bother with extracts etc, preparing a drink from pure root powder is the traditional way of taking kava & the only way that works for me. Its legal in most countries & easily available online.

prescribed meds. I've been on the anti-depressant Dosulepin for several weeks now (I've been reluctant to take anti-depressants for a long time because of the horror stories you hear), but I'm finding this stuff to be very good. Its one of the older tri-cyclic AD's and has a slight sedative effect. Apart from its anti-anxiety properties, I am getting a good nights sleep for the first time in years without having to take benzo's and/or sleeping tablets (which only work short term for insomnia anyway). Its not addictive either according to the doc, & I'm just hoping it keeps working for me like it is doing now.

You have to take it for a few weeks before it starts to work tho. Here's a link..

http://en.wikipedia.org/wiki/Dosulepin

Good luck.
 
Atarax is just another antihistamine. Many doctors do prescribe it for first line tx for anxiety but I don't find it any more effective than benadryl.
 
Alot of exercise and staying busy with a hobby/job etc...are all GREAT natural ways to reduce anxiety. The exercise releases natural endorphins which counteract the negative feelings you may be experiencing and staying busy with a job (or especially a hobby) is good at distracting your mind from overthinking a negative subject/experience and can also produce monetary income!!!(This helps releave stress in most people I know).
 
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