Any cross-tolerance with phenethylamines and tryptamines?

[SizzleSword]

Was just curious, a friend of mine did some 2C-E three days ago and h'es really wantingto try that 5-MeO-DALT stuff out.

Should he expect a diminished experienced or do you think he'd be wasting his material?

Also, what's the best method of ingestion? We hear it shows oral alert effects after just fifteen minutes or so, but I've heard some people say the stuff should be put in the rectum while other people say you're completing wasting it if you smoke the stuff.

Thanks for any suggestions.

 

[Jesusgreen]

Tolerance isn't really so much about which class of drug something falls under, but rather which receptors they affect, with what affinities and such. Most traditional psychedelics for example, including 2C-E, affect the 5ht2a receptors, and I'm pretty sure 5-MeO-DALT does too, so yes there should be cross-tolerance.

3 days is not enough to get rid of that tolerance however it's enough that it won't be ridiculously severe, usually around 1.25x the dose is good for the 3 day mark. However if this is his first time trying 5-MeO-DALT I'd personally just wait until it's been at least a week, ideally 2, then give it a try - so he doesn't have to worry about wasting it or upping the dosage.

Personally I have no experience with 5-MeO-DALT and although I tend to research thoroughly substances I've never tried, 5-MeO-DALT is one of the ones I know very little about, so I can't help with the ROA.

 

[SizzleSword]

Yeah I agree with what you said Jesusgreen and even had posted it on another forum before this reply.


"Yeah, I agree with your last statement with just getting your head clear first, but since both tryptamine and phenethylamines work on similiar (or if not the same) recepetors, couldn't there be a tolerance right there?"

 

[azgaza]

In theory there should be cross tolerance due to 5HT2a/c down regulation, bút I never noticed much cross tolerance between for example LSD and 2c-b or tryptamines and LSD. Dosing 2c-b in a late, late LSD comedown didn't seem to change the needed dosage at all. I'd say 3 days should be enough even if there is some minor cross tolerance, as if I would take the same psychedelic 3 days later at most I'd need 1.5 times the normal dosage, not more.

I'd say space your trips for other reasons though: tripping too often is thé way to get HPPD and the only way to prevent it is spacing your trips apart, because of that I'd advise waiting rather two weeks then three days, but if the two trips in a row is more of a rare thing I don't see a problem there.