How could generalized anxiety disorder and panic disorder effect an IV methamphetamine high/rush and their tolerance level. The same dosage has caused panic attacks at times and strong euphoria other times. The panic usually comes from the belief that they are going to have a heart attack or overdose (even from small doses). Now they are afraid to do it around many or new people because they are unsure of how they will react, so add social anxiety to the equation. They have a fear of even having a panic attack, which makes it worse. They also have difficulty differentiating between symptoms of anxiety and symptoms that are life threatening. Does anxiety/panic increase chance of overdose? How to control anxiety while using stimulants? What could be causing the panic attack since it doesn't happen every time? Benzos are not a good idea based on past experiences with mixing the two.