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Antipsychotics used in depression???

Helios. said:
Ketamine is no antidepressant.

Depression is a spiritual problem. To overcome it, you have to believe in something greater and better than yourself.
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Ya thats only your opinion and your entitled to it. But i think my depression (well actually bipolar depression most likely) is due to a chemical imbalance.

Ive never tried ketamine but i have to say that since ive been put on seroquel my mood has improved greatly. My moods are no longer going up and down like a yo yo on acid and i no longer get those black depressions where i can barely even think.
 
Once upon a time, before these research papers were published, yours truly went around these forums like a raving lunatic, proclaiming.. "Ketamine has healed me! Ketamine has healed me!"... but very few listened. Praise teh loaard!

:D:D

(Btw, I can attest from experience that a small dose of seroquel is capable of "cancelling" a major episode in either direction with bipolar.)
 
I don't have anything against ketamine per se, but using a vial by yourself in one setting is contraindicated.

Back on topic, people seem to like Geodon as well.
 
Jamshyd,very occasional PCP seems superior in "setting things straight",believe me!
 
hugo24 said:
Jamshyd,very occasional PCP seems superior in "setting things straight",believe me!
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Yep, PCP does work to an extent in my experience, and its effects are very long-lasting (I still feel it a week later). However, its efficacy is not as "perfect" as Ketamine's.

Plus, PCP has some strange side effects (such as completely irrelevant semi-psychotic ideas) even at a sub-psychedelic dose.

Since we're on the subject... I found that DXM doesn't work at all. Nitrous works well but the effects fade quickly (but it has a wonderful "purifying" effect on feelings and thoughts). I really want to try Memantine and/or Adamantine to see if they work.

My amature theory is that some kinds of depression (melancholia, suicidal thoughts, constant anxiety...etc) might be caused by over-activity in the Amygdala, and that some NMDA antagonists are able to attenuate this over-activity.

I would appreciate any informed cretique or opinion on this idea...
 
There are certainly a lot of cannabinoid receptors in the amygdala, and cannabinoid use is associated with paranoia anxiety and fear, maybe your theory has some merit.
rats whose amgdalas were electrically stimulated showed classic fear responses. which would correspond to anxiety and feelings of impending doom in humans. Chemical warfare research in this field is still highly classified but it is rumoured that several chemicals were identified that induced fear in animals.
The amygdala is an old brain structure so it might have conserved receptors that are only located here rather than in the more evolutionary recent brain, these receptors if they exist would be a useful target.
 
Helios. said:
Ketamine is no antidepressant.

Depression is a spiritual problem. To overcome it, you have to believe in something greater and better than yourself.
Click to expand...

It's this kind of primitive misinformation that contribrutes to the profound ignorance of mental health issues.
 
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