Nor can I imagine anyone wanting to take them together. But for grins sake, assume someone had been taking Geodon for schizoprenia, was on a stable dose and doing well, I suspect that the euphoria would be present (and welcome). Best I recall there is zero affinity for the opioid receptors, but given how all the circuitry reciprocally affect things like the opioid network, it may not be straight forward. Why we are on the subject--how do salvia lipids such as salvinorin A which appears to be a bad-assed opioid (kappa) receptor agonist produce psychedelic experiences. I know that some academics want to call them dissociative but I aint buying.
My bad--read as BMD, not BPD. Mirtazapine is a good med, one I take myself, and a pretty damn good sleeper that goes underutilized. Figured the gabapentin was for pain, but has been used for bipolar with lousy results. I'd still try it--back in the day, we'd often prescibe small amts of haldol for the same reason. Do you think it helps with the anxiety--shortage of good meds that are not SSRI's or highly addictive benzos....
. I can feel happy, sad, cheerful, aggressive, violent, and many more emotions in one day, sometimes even within a few hours thanks to my BPD.
pubmed.ncbi.nlm.nih.gov
Olanzapine doesn't seem called for based on what you've described but I don't have all the info so who knows.
That said, antipsychotics should generally avoided unless they are absolutely necessary. Especially a pretty heavy duty one like olanzapine.
Personality disorders are tricky to treat, and antipsychotics are a pretty controversial pharmacotherapy for treating them. Personality disorders themselves are controversial.
Here is a decent sized study that evaluated olanzapine's efficacy in treating borderline personality disorder that came up short.
Olanzapine for the treatment of borderline personality disorder: variable dose 12-week randomised double-blind placebo-controlled study - PubMed
Individuals treated with olanzapine and placebo showed significant but not statistically different improvements on overall symptoms of borderline personality disorder. The types of adverse events observed with olanzapine treatment appeared similar to those observed previously in adult populations.
Of course olanzapine can be used for treatment resistant depression in certain cases so again who knows what your history looks like.
Personaly i feel antipsychotics are over used and I believe in time this will be consensus on this. But then again, you might very well benefit from them.
I am not surprised that the results were meh. Hell most trials, even those that reach a p<0.05 generally have a mild impact on the illness. I also agree, and don't get me standing on a soapbox that antipsychotics are over-prescribed and even mixed as in a dab of this a dob of that, usually based on the prescriber's "experience" ie, shorthand for I havent a fucking clue but lets try it anyway, sure there some receptors we haven't bombed.... I get especially incensed when kids are involved. Sure you're gonna be an anhedonic robot, but that will teach you for acting out. But I also know a great adolescent and kiddy shrink who has cases where she is convinced the AP's are indicated. And just going on experience that a) BPD is ego-dystonic beyond belief, and that a low dose trial is worth a shot. Used to call Haldol "personality glue" for the effect seen on internal state regulation.Olanzapine doesn't seem called for based on what you've described but I don't have all the info so who knows.
That said, antipsychotics should generally avoided unless they are absolutely necessary. Especially a pretty heavy duty one like olanzapine.
Personality disorders are tricky to treat, and antipsychotics are a pretty controversial pharmacotherapy for treating them. Personality disorders themselves are controversial.
Here is a decent sized study that evaluated olanzapine's efficacy in treating borderline personality disorder that came up short.
Olanzapine for the treatment of borderline personality disorder: variable dose 12-week randomised double-blind placebo-controlled study - PubMed
Individuals treated with olanzapine and placebo showed significant but not statistically different improvements on overall symptoms of borderline personality disorder. The types of adverse events observed with olanzapine treatment appeared similar to those observed previously in adult populations.
Of course olanzapine can be used for treatment resistant depression in certain cases so again who knows what your history looks like.
Personaly i feel antipsychotics are over used and I believe in time this will be consensus on this. But then again, you might very well benefit from them.