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  • BDD Moderators: Keif’ Richards

Anti depressant and psychedelic drugs

retard

Bluelighter
Joined
Jun 22, 2009
Messages
83
Location
The Netherlands
lately I'm interested in psychedelic drugs, unluckily anti depressants and other drugs do not mix well (serotonin syndrome). However on the Drug FAQ on this website I read this:

SSRIs
Mechanism of Action
SSRIs (Selective Serotonin Reuptake Inhibitors) work by selectively inhibiting the reuptake of serotonin. Thus, more serotonin remains for a longer period of time in the synapses. Although the different SSRIs vary in how effective they are at inhibiting 5-HT reuptake, they all do so selectively, and thus they do NOT have a direct (significant) effect on other NTs.

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Hallucinogens (LSD/Acid, psilocybin/Shrooms, Tryptamines, 2-ct-2,DPT, DMT etc, Salvia): These drugs can be safely combined with the SSRIs. Most people report that they need to take MORE of a hallucinogen to get normal effects. Thus, if you are taking an SSRI, you will probably need more of the drug to reach threshold effects. Some people find that they need to take more LSD, but that shrooms affect them normally. So be careful to start at a normal dose and only take more if you find that you need to.
NOTE: Do not take 'ayahuasca' while on an SSRI. Do not combine SSRIs with any kind of MAOI, such as harmaline.

I know psychedelics work by activating on some of the serotonin receptors but that's all I know.

So can anyone tell me what is safe to do.

Also other people their experiences with anti depressants and psychs I appreciate. :)

Oh I take 60 Mg Cymbalta (Duloxetine).
 
Duloxetine is quite close to the way that Tricyclic Antidepressants, and these seem to potentiate Psychedelics such as Psilocybin. I always take a smaller dose of Mushrooms when they come around due to being on Dosulepin (also an SNRI).
So I would be careful and take less than you normally would do.
 
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