Opioids Anti-biotics as a CYP3A4 inhibitor?

[Justin Sane 53]

I'm on tylenol 4 for a botched knee replacement job as well as doxycycline for an infection. I heard that the antibiotic is actually used to potentiate codeine (which i'm on) so did I read wrong or is this similar to grapefruit juice?

 

[MartinFn]

I have used erythromycin and clarithromycin to potentiate fentanyl,both worked as well(clarithromycin more),but the thing is that you have to wait for some hours to feel it.Some anti-biotics are CYP3A4 inhibitors,so they do the job.It's as you said like the grapefruit juice,but they're stronger than it.I can't tell you for sure,because codeine may work through another way,but i think that they use similar ways.I've try grapef.j and simitidine and they didn't work as well as i was expacted.Erythromycin and clarithromycin more,worked great(But not quickly).I don't think that they gave you doxycycline to potent the codeine,they gave it to you to avoid an infection,but maybe it potentiates codeine too,as a side-effect(hope i write it right..).I wish i help you,have a nice recovery...

MartinFn

 

[monstanoodle]

One thing I'd say is that Antibiotics also decrease the amounts of, what the Yakult adverts would call, "friendly bacteria" as well as the nasty ones that they're prescribed to fight.
So unless you're scripted them for legitimate reasons, I wouldn't go about using them just to potentiate certain substances that would require inhibition of CYP 3A4.

But yes, seeing as you're using them for legitimate reasons, I too wish you a speedy recovery