antagonist desensitisation = agonist desensitisation ?

[SWIMMY]

Hello,

I can't seem to find an answer,

suppose i would take a seretonin antagonist like mirtazapine
A few days later, almost all the mirtazapine would have left my body but my tolerance to mirtazapine would still be there to some degree.

My serotonin receptors would still be somewhat desensitized to it.

And suppose, on that day,I would take mescaline which acts as an agonist, would i have a tolerance to it or a negative tolerance to it ?

i mean, would the effects be more or less ?

anyone knows ?

thanks !