Another amp thread-Amphetamine TIme Release?

[Vice^]

Well moderate tolerance and I took 90mg of time release d-amphetamine. It was milder than I would have liked and started to come down at the 4 hour mark. I read that adderall XR; half the beads release themselves immediately, and the other half releases it self in 6 hours. Is this true? should I be expecting another amphetamine experience in 30 minutes?. I read another site that side dexedrine; the first half of beads is released immediately, the other half is released slowly over a 12 hour period... that sounds vastly inefficient, but what im asking is.. is dextrostat time release, release the other 45 mg in 6 hours like the one site said adderall does??. Slowly releasing it over 12 hours is stupid.. with low amounts of amphetamines peaking in your system at different time creates a very inefficient way of delivery.

 

[Vice^]

Anyone??

 

[human]

I have no idea what the pharmacokinetics of time-release amphetamine preperations are, though it's something I've been meaning to look into as I was recently prescribed adderall XR.

Anyway, if I just take your word for it I would think the difference between slowly releasing it vs. two distinct releases is that with two distinct releases you're going to have two periods of the day where you're distinctly stimulated, whereas with a slow, constant release there would (presumably) be less variance in the plasma concentration over the course of the day/night.

But I dunno I'm just going off your words and intuition here.

 

[Vice^]

I have no idea what the pharmacokinetics of time-release amphetamine preperations are, though it's something I've been meaning to look into as I was recently prescribed adderall XR.

Anyway, if I just take your word for it I would think the difference between slowly releasing it vs. two distinct releases is that with two distinct releases you're going to have two periods of the day where you're distinctly stimulated, whereas with a slow, constant release there would (presumably) be less variance in the plasma concentration over the course of the day/night.

But I dunno I'm just going off your words and intuition here.

Finally a response . Well yes there are major differences between the two delivery systems. I have only found out today how shitty dexedrine is like this. I had always thought the time release to be similiar and dexedrine being better :S. The slow system is terribly ineffective and stupid in my opinion.Sure dexedrine will be in my blood levers LONGER. But the low doses at different times, and different doses peaking at different times, makes this spansule invention just look like a cheap way to make the product look better. If I take 20 mg say, in the morning, I will have only 10 mg in my system during morning class. The other 10 will be released slowwwly over 12 hours- means that less than 1 mg gets released every hour. Or 1.6 mg every 2 hours or however its done. Even iif its at 5mg 4 hours after ingestion and 5 at 8 hours....the max relief will come for only 4 hours, and after taht only 5 mg peaking at one time. I could seriously fall asleep 2 or 3 hours after taking a 20 mg dose. So after typing all that, I hope to god I am wrong and the site I read was wrong. If not, this means I should switch to Adderall I guess 8( 8( .

EDIT: anyone here in the pharm industry or chemistry industry or something that can help me sort this out?? or anyone have any good evidence to support the claim. If I do not find a satisfactory response tonight- I will phone GSK tomorrow and ask.

 

[BilZ0r]

What is the exact brand of pill you've got? We can't answer this question otherwise.

 

[yaesutom]

I get the dexedrine generic SR's (generic spansules), i read there's a difference between the generics in the way they release it compared to the name brand but i might be wrong.

Now "dextrostat" generic if you can get that are the instant release, would last about 4 hours with me. These SR's last about 6.. just a smoother up/down. Honestly I probably prefer the dextrostat tablets, its these damn pharmacies that usually don't carry them (or takes forever to preorder) around here.

Adderall XR, all that is, is it releases half immeidately, and the other half 4 hours later, so the company can patient it and push it to doctors to sell it.

Dexedrine generally has less side effects than Adderall because of the lack of that useless (IMO) levo-amphetamine in there. Especially if your on a high dose.

 

[Vice^]

What is the exact brand of pill you've got? We can't answer this question otherwise.

Dexedrine Spansules 15mg capsules. 1 a day in the morning is supposed to last all day.

 

[Morninggloryseed]

Dexedrine generally has less side effects than Adderall because of the lack of that useless (IMO) levo-amphetamine in there. Especially if your on a high dose.

Slightly off topic, but my findings are the exact opposite. I had to switch from dexedrine to adderall because my body could not take it. Adderall is much 'smoother' for me.

Kind of like comparing (+)-MDMA to the racemate. SUre the isomer is stonger, but it lacks something. The racemate is much more 'rounded' (excuse my subjective descriptions.)

 

[Mr. Robo-Tripper]

I would think that half of it gets released immediatley while the other half gets released slower in 3-4 hrs for the next 4-6 hours. I cant imagine taking 90mg of that...dont you miss the good ol days of 40-50mg spinning you around???

 

[yaesutom]

Slightly off topic, but my findings are the exact opposite. I had to switch from dexedrine to adderall because my body could not take it. Adderall is much 'smoother' for me.

Kind of like comparing (+)-MDMA to the racemate. SUre the isomer is stonger, but it lacks something. The racemate is much more 'rounded' (excuse my subjective descriptions.)

It would be nice to try just plain racemate amphetamine sulfate to compare the others to. With adderall sometimes it DOES feel "better" like more euphoric, but thats only at the beginning with me and ends up turning into the jitters as it wears off. Also tolerance for some reason went waay up way faster than dex.

I guess it matters more when.. your on a high dose. Higher doses of either one cause more side effects, i get 4 x 15mg dex spansules a day and i'm fine with 60mg, but i'd say 60mg of Adderall is usually the top of the dose range - I used to be on 60mg Adderall a day and not only it wasn't strong enough (i'm highly tolerant), but i'd come home from work feeling like *shit* sometimes.

Too bad meth is neurotoxic (at least moreso), because oral methamphetamine is so smooth and free of side effects, I feel so "normal" on it, and have a crazy appetite for food and sex (among other things).

 

[BilZ0r]

Dexedrine Spansules definately have an instant release and an extended release phase. Though there will only be one peak, and an extended half-life. There is nothing "stupid" about that, for therapeutic use.