Hey
@goaway12345 we're happy to help you. Please don't bump your own threads though. That's unfair to everyone else whose' question(s) are just as valid as yours.
I want to help you out. This is a "teach a man to fish" situation in the sphere of online Harm Reduction. You're asking some questions that are pretty well-studied and well-reported. If I were to google your question regarding the "potentiation", you could have very easily answered your own question. You wouldn't have to wait for us. I know this will sound cheezy. The more and faster you learn this stuff, the faster you're able to turn around and spit it back out to the folks asking the questions.
Furthermore, we've talked about this a million times here on the forums. I have spent so much time talking about enzymes and getting high that I'm qualified to teach a seminar.
To throw you a bone:
Grapefruit and similar fruit like Bergamot contain flavonoids that inhibit different enzymes of the P450 family. This group is responsible for metabolizing ~50% of all known drugs.
Yes, certain Benzodiazepines are going to be inhibited via this process.
Truthfully, I've been through this many times in my personal life. I've used drugs for over a decade and though "clean", I still take drugs that are affected by this process. I've never noticed any difference in effects that I could truly, honestly say were any different than had I not taken these things. The thing is, I know from reading that there definitely is SOME kind of effect. This has led me to say that this potentiation couldn't be any more than 20% on the high end.
Again, I couldn't tell you this from subjective experience. I never could truly tell a difference.
If you were to use these, you would probably want to take them an hour or so before taking your Alprazolam (Xanax). Who knows, you might notice a difference. That was just my experience. To elaborate, I've eaten grapefruit, drank grapefruit juice, taken Cimetidine (Tagamet) dozens of times etc.
Methadone is a drug that would be more affected by these enzyme changes. The only time with any drug that I truly believe there was a difference was when I took antacids before Methadone; that's antacids in general. This could be Cimetidine, Tumes or Bakind Soda. I hope this helps.