amt profound long lasting nausea/vomiting

[thundercrane]

Wanted to discuss the issue of nausea and vomiting on amt (please re-categorise this if it should go elsewhere) yesterday I took 60mg orally and the initial comeup was sugarsweet. 30 mins later however and im dripping with sweat shivering teeth set on edge and totally dysphoric. This state persisted with waning strength for the next day and has now all but subsided. I had bought a twenty bag of pot earlier to combat the vomiting but joint after joint proved ineffective.
The only things that ive heard attack the source of the problem (5ht? activated causing nausea) are benign medications such as ondansetron mirtazapine (will abort trip) and Cinnarizine.

 

[stilllost]

try a much higher dose and see what happens

 

[Solipsis]

Don't listen to stillost, that is horrible and irresponsible advice - and probably not serious.

You are answering your own question: the nausea would mostly be mediated by the 5-HT3 receptors and yes I hear ondansetron works well. Mirtazapine is too unselective of a serotonin antagonist so like you said we can forget about it.

Unfortunately I don't have a solution to offer, some people seem to get this and others don't. Cannabis might have helped - some might have expected it to, but in general treating one mechanism of nausea while another one is actually responsible often does no more than take the edge off.

I would like to mention as well that I installed a poll in our AMT thread a while back to ask about how prevalent nausea with it is. Check it to see current results:
http://www.bluelight.ru/vb/threads/611377-The-Big-amp-Dandy-AMT-MT-Thread-(4th-Rush)

 

[construct]

I have heard AMT taken rectally can reduce nausea. I believe it should be converted to the HCL first, though. I read this stuff in the second Big and Dandy AMT Thread.

 

[Achten]

try a much higher dose and see what happens

Not sure if trolling ...

Anyway 60mg's is a hell of a dose already. Well, it would be for me anyway.
Maximum I took was 40mg, but my comfort zone is around 30mg.
That gives me a whole night of empathy and visual play. If I want to lose myself in another world visually I''d take another compound.

Cannabis should help with nauseau, but maybe try ginger ?

 

[Jesusgreen]

I've noticed when discussing with people which people got nausea from aMT and which people didn't get any, the resounding answer seemed to be that those taking the Freebase form experienced nausea, while those taking HCl felt fine.

Do you have access to the HCl form in future? You could try that and see if it's better for you.

You could also try converting the freebase to HCl or another salt by adding the corresponding acid, e.g. Fumaric acid to make fumarate, Hydrochloric acid (also known as Muriatic acid) to make the HCl salt.

It might just be how the drug feels for you though and not relevant to whether it's salt or freebase. Did you smoke weed before the nausea started? I know weed usually helps nausea but in the case of aMT I've seen many cases where people were nausea free or only experiencing mild nausea and taking a few hits on a joint made them run to the sink/toilet to projectile vomit.

Ginger and Diphenhydramine are great for helping nausea, as is Ondansetron. Also as previously mentioned, taking it via another ROA can be helpful. I've only taken aMT via vaporisation and orally, orally it produced nausea but when vaporised there was none. Just bear in mind of you take it through any ROA other than oral you'll need to reduce your dosage.

Hope this helps

 

[sekio]

those taking the Freebase form experienced nausea, while those taking HCl felt fine.

That doesn't make a lot of sense; the acid counterion in a drug salt should be totally inert, and orally administered AMT would invariably end up as a HCl salt in your stomach anyway. Stomach acid is something like 0.5% HCl by weight - pH 1.

 

[psood0nym]

^I've wrestled with that same thought as it was happening yet I've known it to be true. Logically, I have to assume it owes to some unknown impurity between the particular salt or freebase I've possessed, or circumstance, yet there I was sick (or not) in spite of it.

 

[Jesusgreen]

That doesn't make a lot of sense; the acid counterion in a drug salt should be totally inert, and orally administered AMT would invariably end up as a HCl salt in your stomach anyway. Stomach acid is something like 0.5% HCl by weight - pH 1.

I'm not quite sure why it is either that people have reported this, my only thought could be that the freebase is degrading and something it's degrading into is causing the nausea. I'm not sure what aMT degrades into, but I know the freebase is certainly unstable.

It could just be that those people were taking similar doses of freebase and HCl though, and finding the bodyload from the freebase worse, since the freebase is a little more potent.

 

[sekio]

Maybe the freebase just irritates the stomach lining more. It's also 1.2x as strong as the HCl salt - that may defs play a role too.