Amphetamines and vitamin C

[arrall]

There are a dozen articles over the next 20 years from this one that report the correlation between acidic urinary Ph and excretion rate of amphetamine and methamphetamine.

I always assumed that Vitamin C's decrease in concentration and sodium bicarbonate's increase were due to the effects on stomach pH. It's interesting to see that it is actually due to urine pH.

Another great study that I found very interesting is BECKETT, A. H., & ROWLAND, M. (1965). Urinary excretion kinetics of amphetamine in man. Journal of Pharmacy and Pharmacology, 17(10), 628–639.

 

[Jabberwocky]

I always assumed that Vitamin C's decrease in concentration and sodium bicarbonate's increase were due to the effects on stomach pH. It's interesting to see that it is actually due to urine pH.

Another great study that I found very interesting is BECKETT, A. H., & ROWLAND, M. (1965). Urinary excretion kinetics of amphetamine in man. Journal of Pharmacy and Pharmacology, 17(10), 628–639.

Not just urinary pH. Specifically pH in the tubules in the kidneys unless there has been some new discovery since the 70’s. The kidneys act like a valve switching some % of amphetamine towards excretion and the remaining % towards reabsorption and continued potential psychoactivity. The pH in the kidney tubules controls the variable position of the valve.

 

[Jabberwocky]

seems like Beckett was the go-to guy on this topic back in the day

 

[Jabberwocky]

I always assumed that Vitamin C's decrease in concentration and sodium bicarbonate's increase were due to the effects on stomach pH. It's interesting to see that it is actually due to urine pH.

Another great study that I found very interesting is BECKETT, A. H., & ROWLAND, M. (1965). Urinary excretion kinetics of amphetamine in man. Journal of Pharmacy and Pharmacology, 17(10), 628–639.

Except Vitamin C doesn't acidify urine to any significant degree:

1000mg 4x/day for 5 days - not statistically significant

Effect of ascorbic acid on urine pH in patients with injured spinal cords - PubMed

The ability of ascorbic acid to lower urinary pH in patients with spinal cord injury and neurogenic bladder was studied. Ascorbic acid (1 g four times daily) or placebo was administered for five days in a double-blind, crossover study to 20 patients with spinal cord injury and neurogenic...

pubmed.ncbi.nlm.nih.gov

2 grams 3x/day a change of .16-.18 in pH, again not statistically significant

"Therefore, vitamin C can not be recommended to lower the pH of alkaline urines."

[Modification of urinary pH through ascorbic acid] - PubMed

The influence of orally administered ascorbic acid on the urinary pH of 10 healthy volunteers and 10 patients with infected urine was investigated. During a four-day period of investigation urinary pH and the concentration of ascorbic acid in the respective urines were measured five times a day...

pubmed.ncbi.nlm.nih.gov

 

[Jabberwocky]

It does seem that vitamin c may directly lower levels of amphetamine and possibly methamphetamine in the body.

Apparently, ascorbic acid will deaminate amphetamine in the presence of oxygen buffered to a pH of 7.0

Ascorbic acid also apparently lowers the level of amphetamine in dogs.

THE ACTION OF VITAMIN C AND PHENOL OXIDASE IN THE INACTIVATION OF BETA PHENYLISOPROPYLAMINE (AMPHETAMINE)

That amphetamine is capable of undergoing inactivation in the body and the means whereby this may be accomplished have been described. Through the intermediation of a monohydric phenolic compound ( p -cresol) phenol oxidase has been shown to be capable of activating the deamination of beta...

jpet.aspetjournals.org

 

[Jabberwocky]

If you really want to lower your urinary pH, without taking ammonium chloride or other harsh chemicals, eat lots of meat and cheese.