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  • BDD Moderators: Keif’ Richards

amphetamine dosage after break

admiral halsey

admiral halsey

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Joined
Mar 18, 2013
Messages
10
For ADD, Ive taken vyvanse every day for about 7-8 months (have been at 70mg the past 4 months) and have developed a significant tolerance. I have learned that while tolerance is inevitable, a low tolerance can be prolonged (knowledge I wish I had when starting the medication).

I plan on trying tolerance prevention/reduction. I've gotten some fantastic information from reading posts here. However, I still have some questions:

-After a 2 week break (too much/too little?) what dose should I cut back to?
-Would a 2-3 day break every week be enough to prolong a low tolerance?

I'm not trying to get the initial euphoria back. Rather, I want to regain the motivation and interest (it was nice to be interested in something for once) I've tried magnesium citrate for about 1.5 months, but havent noticed any change.


One final question..
There's a lot of info on here about DXM and tolerance reduction. However, I take lexapro. While I've found many reports strongly advising against DXM + MAOIs, I've seen mixed reviews about DXM + SSRIs. Is there a significant risk of serotonin syndrome when taking the recommended dose (or perhaps even less as a test) of Delysm while on an SSRI?
 
Get chelate as its drastically more effective and beneficial for these purposes.

Amp tolerance does cause noticeable issues with my usual 5 day break, its minor but increased side effects are the symptom, but not really any increased dosage required for the positive effects.

A two week break with daily ch mag usage and therapeutic dxm use at 60mg or so for the tolerance benefits did result in drastically improved experience and reduced side effects but again not necessarily a dose related impact. I am certain the dxm does help to some degree.

Weekly breaks are fine for sustained results but a two week dose does make a difference as well.
 
Two weeks will put a bit of a dent in your tolerance, but within a week you are more than likely going to be right back where you were to begin with. Not to mention the probable consequences to your life and workload etc caused by the slump from not taking your Rxed stim. But...lesser of two evils, I suppose.

You probably won't want to start any higher than 30-50mg. For a few days, at least. You may be pleasantly surprised and it may be more than you need. Also, a break on your weekend (or your two least demanding days) would help keep your tolerance low, but it won't stop its growth dead in its tracks.

It has been determined in at least one case study that recreational doses of DXM are necessary to cause serotonin syndrome when in combination with an SSRI.

http://www.ncbi.nlm.nih.gov/pubmed/19238739
 
Yeah i forgot to mention i regularly use 60mg range doses daily of DXM combined with SSRI's without issue. Is risky though in theory so ensure proper analysis of the risk vs reward in your own situation to be safe.

I think once I even took a bit more DXM then usual while on lots of meth as well as my high SSRI dose and it was seemingly ok. Dont do silly things like that but it might help to illustrate the safety margin and help with proper care and planning in this regard without unnecessary paranoia getting in the way of accessing the benefits from this if it could really help you inm some way.
 
There is still some risk of it occurring, but I believe it to be relatively slim when we are talking of therapeutic doses of both medications. By all means start low. Most adult preparations are at around what, 30mg/5ml(6mg/ml)? Work your way up from 1mg if you're feeling uneasy and you see the risk worth your potential reward. Risk vs. reward is a good thing to consciously assess when it comes to drugs/medication. Often enough, it falls away from the conscious and into the unconscious processes, where we may not be honestly weighting the factors so that they truly represent reality.
 
Great, thanks for the info. Ill try a low dose of DXM tonight and see how it goes.

I completely agree about the importance of rational risk vs reward..it really is amazing, the persistence of desire and the timidity of rationale....we sure are interesting creatures.



I was wondering...how would changing to a different amp work? Would I have a very low tolerance or would I maintain my current tolerance?
I know they all affect neurotransmitters, but do different forms have individual mechanisms (with separate tolerances)?

random question...should I be concerned about psychosis at 40+ hrs w/out sleep (school) & daily 70mg vyvanse?
 
You would by-and-large maintain your current tolerance.

No, not unless you're normally susceptible to psychotic tendencies, but that's not healthy.
 
I don't think switching to a different amp would work. The average doses for adderall and dexedrine are lower, but that's just because they're more potent/shorter acting. I don't think you should be concerned about psychosis. I've stayed up for that long on adderall, but you should try getting some sleep asap.
 
I don't think switching medication would change things to be honest. It's just a matter of managing your tolerance.
 
do NOT take DXM on a SSRI. this will cause SS (serotonin syndrome). wait atleast 2-3 days if you have been on a SSRI for over a month to, and then take the DXM. wait 1-2 days, after the DXM to gp back on SSRIs


id dump the SSRI. they all have nasty side effects and dont really do shit to help with addiction/ anxiety/depression IMO. they make me feel more depressed because they make me put on weight; reduced my sex drive is drastically coupled with weight gain made me feel even more insecure. get off them while you can!

Please do not tell members to go off their Rxed medication. These decisions should be taken under medical supervision, regardless of whether or not it is a commonly held opinion.
 
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^ There is evidence (above) that therapeutic doses of DXM while on an SSRI regimen, in the average individual, will not induce SS.

As always, tread with caution and titrate doses from sub-threshold levels.
 
I appreciate your concern Lacster, but I was fine w/ 15mg DXM.

I'm sure SSRI's can help anxiety/depression, and potential side effects aren't that bad. I think they're worth a shot, right?
 
Hey Man.,

An SSRI alone isn't going to give you the effect I believe you are in search for. These two types of medications are commonly combined. Doctors make these decisions based on whether or not the benifit outweighs the risk.-- (IMO)

However, I read earlier tonight SSRI's are a Major Risk combined with CNS/ Psychostimulants. To be perfectly honest with you I have always leaned more towards realism and come to the conclusion that most informative drug articles are implemented on the "let’s be safe not sorry." motto. Which lets face it quite frankly isn't a bad one.

My opinion for what that’s worth- Which is absolutely nothing- “Concrete Thinkers” obligate themselves to explain interactions of any caliber or any drug can result in death. When in actuality 10's of millions of people worldwide are under a physician’s supervision with a treatment plan consistent to SSRI+D-Amp, Amp, LD-Amp Dimesylate, as well as Methelypheidate compounded medications. Then there is another realm of it- The self-medicating population whom are reading the same material and heading straight for the medicine cabinet preparing to double dose 1, 2, 3 of each.

My philosophy is simply this- How much is it really worth. What I mean by that is- Is it really worth the gamble. Well my opinion is no, not at all. That’s a question only you can ask yourself. If they say don’t, think it over diligently, once you've done that then base you decision on how you feel.

Only you know your body and what it can handle, we don’t. The fact of the matter remains; people have suddenly died from very small amounts these medications. While others have taken 10-15x that same dose and live to tell the tale.

Be smart, make your own decisions. The key here is- Most importantly stay safe and smart. If you have to question yourself than respectively you can appreciate the fact that it contains some validity .In turn it's probably best to avoid it.

Sorry for being such a square, I just want to give you my angle. That’s what these thingsare for, right..?

Best of Luck to You

P.S. - Feel free to inbox me with any questions or concerns, I’d be glad to help in any way that I can!
 
laCster said:
oh blow me. i can have my own opinion.,,

SSRIs are bullshit
Click to expand...

You can have your opinion, no one is even denying you that; What you can't do is tell a person in need of psychiatric medication to discontinue their treatment.

I would probably be one of the first people to admit that doctors Rx SSRI drugs like candy, almost at random, and just cycle until they find one that works. Unfortunately it is the state of affairs atm.
 
laCster said:
oh blow me. i can have my own opinion.,,

SSRIs are bullshit
Click to expand...

laCster, although the anti-SSRI crews have valid reasoning's, the facts however which speak the loudest, confirm that many people benefit from SSRI drugs for reasons that we cannot contemplate and comprehend since their pharmacology remains somewhat vague.

If you want to pass on medical advice, make sure the user you are addressing understands that it's your opinion. Recommendations that users leave their psychiatric medications can be viewed as cynical, and may cause more harm than good. This is something that you rectified in your second post, unfortunately followed by profanity. There's no reason to be telling people to 'blow you', give respect to those who give you respect, and nothing more.

Just somethings to keep in mind buddy.
 
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