amphetamine affinities for alpha2 receptors

[Dr. Beat]

I have read a few times that Dex-amphetamine and Meth-amphetamine have affinities for the alpha2 receptor, but i cannot find what affinities, or if they are agonist or antagonist.

Does anyone know ?

 

[fastandbulbous]

Funny, I always thought they were indirectly acting sympathiomimetics

 

[5-HT2]

^^^me too. I'm sure they bind to alpha-adrenergic receptors, the question is whether they do it at behaviorally relevant concentrations.

 

[Jamshyd]

I believe it is mentioned in the cooper et al book, though I do not have a copy of the book at the moment.

But if memory serves, it is an antagonist, which makes sense.

 

[BilZ0r]

Amphetmaine hits up the alpha2 receptor with affinity around 1uM, so it doesn't really matter one way or the other whether it's an agonist or antagonist.

 

[fastandbulbous]

Sorry, my post should have had afterwards, at pharmacologically significant concentrations.

That's me though, lazy & sloppy!