ADs definitely have massivley varying effects from one patient to another, this may be a result of the actual underlying reason fro the depression or anxiety or maybe a lot more is at play.
For me all thwe SSRIs I've taken have made me very ill, ranging from severe psychological issues to just plain throwing up. Tricyclics seem to have little to no effect at all good or bad.
I've tried a few other random ones, but Venflaxine has been the only one to provide a stable and at least partly positive effect, wher as I know others have had a terrible time on tnis stuff.
I'm giving serious thought to comming off them TBH, I have little emotion good or bad whihc is OK for a while but gets a bit earing after a while and is having knock on effect in the rest of my life in relating to other people, but scarey though