Drug combinations can be very dangerous, you will eventually find out if you keep this habit, i recommend stopping before any permanent damage is done. Now regulation of those drugs is a whole different story, maybe one day just some dabs and beers, next day xanax and dabs or whatever you feel, though uppers and downers usually dont go good at high doses and causes stress to your brain and will mess with your chemicals (i.e serotonin and dopamine)