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Am-694 and smoking blends WARNING

i am sure that the user to whoam the message was adressed has understood me and there is no need for you to add any unnecesary comments !

bye
 
This is an open forum, so write your stuff in a language that everyone can understand. Everything else is just a bullshit-excuse and secretiveness...

I think nobody minds if I translate it (it's romanian by the way, or something very similar):
I saw you tried AM 694 .. Can you give me more details, too? I am very interested to get it myself .. To what price did you get it?
Did you try to use it to create a blend?

Gimme a PM if you can!
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:\
 
Orangutangpsychopa said:
No-non-no. White eurasian male knows what "KIIMA" is. it's "Want to have a baby" from the women view of point. It's science when they explain the replacation precess-pressors.

He,if is a real wizard, should do them much as can.

"Territory" by Sepultura, gipsies are rebelling again and it's testing process going on.

PS: Black persons are better drug users but it's hopeless for them (no bush support) to figure how caucasians think and proceed.
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o_O' ?

Are you randomly copy-pasting words from the internet putting them together to make some sort of Dadaistic statement?
Seriously.....get urself toghether and use some proper English cause no one on this who entire forum understood what da bloody fuck you are saying.

I'm honestly starting to think that ur using some sort of online translator for your posting.

Mate, either you get right on track or sobner or later you're going to get heavily bashed and probably banned.

And please....even if I didn't catch a word of what you are trying to say...try to stay on topic, cuz it is obvious that whataver u said had nothing to do with the rest of the thread.
 
wow, this is one of the most derailed threads i have ever read - including some of the trash heaps on PD and TR. someone should clean out the gibberish and lets get back on track.

there is a new report of someone smoking, i kid you not, 50mg doses of AM-694 which is utterly astounding considering this one binds to CB1 with picomolar affinity. He suggests the duration is quite short - the subjective effects are calm and anxiolytic - and there seems to be a ceiling on the intensity of the high which makes it difficult to go too far.

what seemed like a RC disaster may turn out to be a quite benign and satisfying chem, but there is still no way im smoking this one. also the person who reported the 50mg dose probably has one of the highest cannabinoid tolerances in human history, he also describes repeatedly smoking 50mg doses of JWH-018. he should probably be studied.
 
hamhurricane said:
wow, this is one of the most derailed threads i have ever read - including some of the trash heaps on PD and TR. someone should clean out the gibberish and lets get back on track.

there is a new report of someone smoking, i kid you not, 50mg doses of AM-694 which is utterly astounding considering this one binds to CB1 with picomolar affinity. He suggests the duration is quite short - the subjective effects are calm and anxiolytic - and there seems to be a ceiling on the intensity of the high which makes it difficult to go too far.

what seemed like a RC disaster may turn out to be a quite benign and satisfying chem, but there is still no way im smoking this one. also the person who reported the 50mg dose probably has one of the highest cannabinoid tolerances in human history, he also describes repeatedly smoking 50mg doses of JWH-018. he should probably be studied.
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I agree. And LOL @ your last sentence.

I guess I'll remain on the fence about this until more is known about it.

JWH's are carcinogens? That sucks, and it's not like with the carcinogens in pot, where THC bonds to old cancer cells and kills them off, no such upside with JWH. I guess I dun right sticking to regular good ol booda.
 
Sorry to put a downer on this thread, but here's my little story. In Ireland, like many other countries, we have stores that sell uncontrolled substances. We call them head shops. Unfortunately in the last few weeks, almost all these "legal highs" have been banned. Since the banning of the JWHs, this new AM-964 product quickly became immediately available, filling the shoes of JWH compounds. For the record, friends of mine have reported that it's nowhere near as good. Nevertheless I was eager to try when I heard of it. But since its release, two people I know have been hospitalised, both for displaying severe psychiatric symptoms. One actually had to get sectioned. I love drugs, but you can count me out on this one.

I'd try anything, but seriously people, this drug is just too new to the world. For me anyway.
 
hamhurricane said:
there is a new report of someone smoking, i kid you not, 50mg doses of AM-694 which is utterly astounding considering this one binds to CB1 with picomolar affinity. He suggests the duration is quite short
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Impressive. I did a doubletake when i read that report. That is by far the most extreme example of cannabinoid tolerance i've heard of.

I am pretty sure that the reported 0.08nm affinity is an error - 0.80 is much more reasonable, and is consistent with anecdotal reports of potency (a little stronger than JWH-018). I don't have access to the original paper to even check that fact.

I thought he said that the duration was longer than JWH-018?

Can't seem to find the post at the moment...
 
rcman1 said:
But since its release, two people I know have been hospitalised, both for displaying severe psychiatric symptoms. One actually had to get sectioned. I love drugs, but you can count me out on this one.
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can you elaborate on the hospitalizations please? what sorts of psychiatric symptoms where they affected by, what doses were they using and how did they recover afterwards?
 
rcman1 said:
Sorry to put a downer on this thread, but here's my little story. In Ireland, like many other countries, we have stores that sell uncontrolled substances. We call them head shops. Unfortunately in the last few weeks, almost all these "legal highs" have been banned. Since the banning of the JWHs, this new AM-964 product quickly became immediately available, filling the shoes of JWH compounds. For the record, friends of mine have reported that it's nowhere near as good. Nevertheless I was eager to try when I heard of it. But since its release, two people I know have been hospitalised, both for displaying severe psychiatric symptoms. One actually had to get sectioned. I love drugs, but you can count me out on this one.

I'd try anything, but seriously people, this drug is just too new to the world. For me anyway.
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How do you know it's AM-694 that's in these new blends? Are you just speculating or have you got evidence? Also most reports i've seen say AM-694 is better than JWH series but I guess it's down to individual tastes.

Have you got anymore information on the hospitalisations? How much were they smoking? If it's just light smoking i'd be worried but some people hammer the smoking blends and pure cannabinoids in which case it's their own fault really, over use of any drug with have side effects.
 
StingRei said:
I agree. And LOL @ your last sentence.

I guess I'll remain on the fence about this until more is known about it.

JWH's are carcinogens? That sucks, and it's not like with the carcinogens in pot, where THC bonds to old cancer cells and kills them off, no such upside with JWH. I guess I dun right sticking to regular good ol booda.
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"JWH's are carcinogens?"

That's a theory. Might be true, might not be. Either way cannabis smoke is KNOWN to have carcinogens in it.

"and it's not like with the carcinogens in pot, where THC bonds to old cancer cells and kills them off, no such upside with JWH"

JWH is effective in anti-cancer studies...just like THC and other cannabinoids. You don't know what you are talking about. :\
 
golden1 said:
"JWH's are carcinogens?"

That's a theory. Might be true, might not be. Either way cannabis smoke is KNOWN to have carcinogens in it.

"and it's not like with the carcinogens in pot, where THC bonds to old cancer cells and kills them off, no such upside with JWH"

JWH is effective in anti-cancer studies...just like THC and other cannabinoids. You don't know what you are talking about. :\
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Erm, I do know what I'm talking about to a certain extent. You really have nothing but spotty evidence at best that JWH may be effective against prostate cancer (that is all that my searching came up with). Link us to some better stuff if you wanna be taken seriously.
 
Many cancers display CB receptors, and CB's make the cancer unhappy.

But nobody is proposing that the JWH's are in and of themselves carcinogenic, but rather that they are metabolized in vivo to carcinogenic metabolites. So they might very well fight cancer, and then be metabolized into something that can cause cancer elsewhere in the body. There are animal studies indicating that one of the napthoyl indole CB's (not one that's used recreationally) was carcinogenic (due to metabolism to the epoxide) and since the first step in metabolism is n-dealkylation, all the napthoylindoles should behave the same way...
 
I am somewhat disappointed with AM-694. ordered 500mg and it's gone already after 5-6 days of use. The high feels somewhat lengthy, but it doesn't push further than a certain level with higher doses. In addition, there is a mild headache. All in all, not too special as compared to 073.
 
TheAzo said:
Many cancers display CB receptors, and CB's make the cancer unhappy.

But nobody is proposing that the JWH's are in and of themselves carcinogenic, but rather that they are metabolized in vivo to carcinogenic metabolites. So they might very well fight cancer, and then be metabolized into something that can cause cancer elsewhere in the body. There are animal studies indicating that one of the napthoyl indole CB's (not one that's used recreationally) was carcinogenic (due to metabolism to the epoxide) and since the first step in metabolism is n-dealkylation, all the napthoylindoles should behave the same way...
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They've shown carcinogenic effects from the metabolites then? Do you have a link? I think I know what you are talking about, but I still don't remember it showing anything certain at all. Do we know what the metabolites are exactly, straight naphthalene or what?

Erm, I do know what I'm talking about to a certain extent. You really have nothing but spotty evidence at best that JWH may be effective against prostate cancer (that is all that my searching came up with). Link us to some better stuff if you wanna be taken seriously.
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many studies show that both cb1 and cb2 receptors when agonized have positive effects on cancer, not necessarily in humans, but still. All you have to do is search cb1 cb2 cancer in google scholar. I don't see why JWH would be excluded from this.
 
No I don't think carcinogenic effects themselves have been found (to establish that requires long-term animal studies, currently), only markers of it, quite far up the chain of causation as it were. Epoxide metabolites have been found, which are known to react with the adenosine nucleotides in DNA, possibly resulting in mutation in oncogenes or other genetic causes for cancer. We have not fond actual genomic damage, however, AFAIK - although it can be reasonably assumed they will do this at least a little bit, maybe not as effectively as other epoxides - no-one yet knows, but i'd suspect it to be less severe than many other epoxides, though of course not harmless.

And - indeed - there's nothing special about some CB2 agonists compared with others in respect to their anticancer effects, the effect is mediated through the action of the CB2 receptor in a mostly ligand-agnostic way.
 
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I thought it was mediated by the CB1 receptor?
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The CB2 receptor, which is located for the most part outside of the brain, seems to mediate many of cannabinoids' immunological and anti-inflammatory effects, mediating few if any of the psychoactive effects. I believe that the CB1 receptors are involved in the former two as well though. . .
 
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