Please read the older big&dandy threads for JWH-018 and related cannabinoids.
I have no experience with AM-2201 directly, but it should be similar to JWH-018 which I have baked into oral treats.
Much like natural THC, synthetic cannabinoids are hydrophobic (don't dissolve in water) and thus are prone to wild idiosyncrasies in oral dosing. I would say a properly prepared oral dose should be comparable in potency to the same weight of smoked dose.
1. Get a box of brownie mix, or use your grandmother's recipe.
2. Using the amount of oil or butter that the recipe calls for, heat the oil or butter in a small pan over medium-low heat and stir in the appropriate amount of your cannabinoid. Here appropriate amount is usually 12 times your standard smoked dose, with the idea that you will cut the pan into 12 identical pieces for easy dosing. NOTE: once this step has been performed, you should treat the recipe as a biohazard--- do NOT lick your fingers, do NOT lick the bowl, and dear GOD make sure to keep out of reach of children or animals.
3. The cannabinoid should dissolve easily into the oil or butter. Remove from heat and cool to room temperature.
4. Bake as prescribed. Individually wrap each piece and label appropriately to avoid any overdose situations.
Done properly, an oral dose of 10mg JWH-018 in this manner begins showing effects 15 minutes after ingestion, regardless of previous stomach contents. Peak effect at about T+1, with gradual dropoff of the next few hours. AM-2201 probably has a similar profile. Be aware that 10mg of JWH-018 here was a FULL ON dose, with overdose/vomiting achieved at 20mg. I strongly suggest that you start with HALF a brownie (ie, half your normal smoked dose) when you first sample the batch, and DO NOT smoke during that day so you can accurately gauge the effects for future reference. Note-taking is KEY when dosing foods!
EDIT: AM-2201 may be approximately 4-5x the potency of JWH-018 (depending on the purity i guess) so I would strongly caution that you put NO MORE than 48mg in your first batch of brownies, so that each piece will have 4mg (and you can still eat just half on the first try)