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alphaphenethylamine???anybody...

T

toxide

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Mar 21, 2006
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Does anybody know what if any would be the effects of alpha phenethylamine or any 1-phenethylamines in general
 
Sounds like it wouldn't do anything?
Maybe it's sold for experienced chemists to make amphetamine, or other chemicals.
 
EDIT: Haha. "Looks like menthol". Yeah it does at quick glance, but only so much when I'm drunk ;). Forget I said anything about menthol :P
 
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toxide said:
Does anybody know what if any would be the effects of alpha phenethylamine or any 1-phenethylamines in general
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I'm old fashioned to me these are alpha methyl benzylamines

the 3,4 methylenedioxyalphamethyl benzylamine is active as a stimulant.
the 3,4 MDO alpha ethyl benzylamine is also a stimulant and mentioned in pihkal.
I did a search on these compounds a long time ago, I cannot remember anything interesting, especially with compounds unsubstituted on the phenyl ring.

in general though the alphamethylbenzylamines are more useful for chiral reductive alkylation/amination and resolution of chiral amines, as the benzyl group can be easily removed by catalytic hydrogenation.
V
 
I was more interested in wether or not they had any 5ht/dopamine activety
one compound that cought my interest was 34dimethoxynbenzyl1pea
 
PiHKAL:
"The benzylamine counterpart (as if one were to move the amine function from the beta-carbon to the alpha-carbon of the three carbon chain of the amphetamine molecule) is alpha-ethyl-3,4-methylenedioxybenzylamine or 1-amino-1-(3,4-methylenedioxyphenyl)propane, ALPHA. The hydrochloride salt has a mp of 199-201 °C. At low threshold levels (10 milligram area) there were eyes-closed "dreams" with some body tingling. The compound was not anorexic at any dose (up to 140 milligrams) and was reported to produce a pleasant, positive feeling. It is very short-lived (about 3 hours). The N-methyl homologue is alpha-ethyl-N-methyl-3,4-methylenedioxybenzylamine or 1-methylamino-1-(3,4-methylenedioxy-phenyl)propane, M-ALPHA. It is similar in action, but is perhaps twice as potent (a plus one or plus two dose is 60 milligrams) and of twice the duration."
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All I mostly know about them is that they've been investigated as MAOIs (with n-substitution) and anoretics. The anoretics developed from them were supposedly without much stimulant action.

edit:
Here's something kind of interesting, 2,3-DiCl-a-methylbenzylamine is an inhibitor of MAO-A and B, but the ratios change based on the stereoisomer.
The (+) isomer of 2,3-dichloro-alpha-methylbenzylamine inhibited the oxidation of serotonin (a substrate of type A MAO) by rat brain mitochondrial monoamine oxidase (MAO) more effectively than it inhibited the oxidation of phenylethylamine (a substrate for type B MAO). In contrast, the (-) isomer inhibited phenylethylamine oxidation more than it inhibited serotonin oxidation. These apparently are the first pair of stereoisomers observed to have opposite selectivity as inhibitors of types A and B MAO.
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I dont think 3,4 diMeO Beta-phen... is even active ...
none of them are remotely active in any sense besides the aforementioned ones
 
Maybe they would potentiate other phenethylamine psychedelics so you need not to dose as much with rare expensive chemicals.
 
Well actually I was wondering cuz they're dirt cheap
And I would always start real low when working with maois
 
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