[Alpha-blockers] Clonodine vs Guanfacine

[Madrus]

Specifically in combination with stimulants.
What differences would you expect to see between these two?

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The main differences between the effects of clonidine and guanfacine on hypertension are: guanfacine activates presynaptic alpha-adrenoceptors 10 times more selectively than clonidine; guanfacine has an alpha 2/alpha 1-selectivity ration 25 times higher than clonidine

 

[arrall]

Clonidine seems to be far more sedating.
I haven’t tried Guanfacine but I believe that it also has milder side effects.
Guanfacine is generally the one used in combination with stimulants to treat ADHD for a reason.