[Alpha-blockers] Clonodine vs Guanfacine

[Madrus]

Specifically in combination with stimulants.
What differences would you expect to see between these two?

Clonidine and guanfacine--comparison of their effects on haemodynamics in hypertension - PubMed

The pharmacology of central alpha-adrenoceptor-stimulating agents is discussed, with particular reference to clonidine (Catapres; Boehringer Ingelheim) and guanfacine (Estulic; Sandoz), and their haemodynamic effects are compared and contrasted. The main differences between the effects of...

pubmed.ncbi.nlm.nih.gov

The main differences between the effects of clonidine and guanfacine on hypertension are: guanfacine activates presynaptic alpha-adrenoceptors 10 times more selectively than clonidine; guanfacine has an alpha 2/alpha 1-selectivity ration 25 times higher than clonidine

 

[arrall]

Clonidine seems to be far more sedating.
I haven’t tried Guanfacine but I believe that it also has milder side effects.
Guanfacine is generally the one used in combination with stimulants to treat ADHD for a reason.