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alpazolam metabolites

twoci

Bluelighter
Joined
Apr 8, 2005
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145
The predominant metabolites are (alpha)-hydroxy-alprazolam and a benzophenone derived from alprazolam. The biological activity of (alpha)-hydroxy-alprazolam is approximately one-half that of alprazolam. The benzophenone metabolite is essentially inactive. Plasma levels of these metabolites are extremely low, thus precluding precise pharmacokinetic description. However, their half-lives appear to be of the same order of magnitude as that of alprazolam. Alprazolam and its metabolites are excreted primarily in the urine.
Simply out of curiosity, how easy would it be to remove the hydroxy group from the alpha position and get alpazolam?
 
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