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Alcohol Alcohol Megathread

SunriseChampion said:
I'm slowly dying inside from lack of footy. My soul is withering away.



Yeah, alcohol is indeed fucking ridiculous and dangerous and a prime example of the irrationality of our drugs laws.



I'm also decent at keeping to myself, though I'm quite social. I'm just good at being with myself and my own thoughts, but yeah, I'm humping the first person I run into when this is all done. And immediately going to a damn nice restaurant and spending like 200$ for dinner. Like the day they open.
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When you say 'footy', do you mean real footy or that bastardised yank version that we'd call rugby for poofs?
 
gee, yknow alcohol is fairly euphoric for the first couple but after that the euphoria kinda dissipates and your left with inhibition. and boy can inhibition instigate some awesome memory's. as long as you don't over do it. to me that's is euphoria good times doing crazy sh*t with family and friends that you'll remember forever. or if you don't remember what happened somebody else will and you'll know you had fun.
 
F.U.B.A.R. said:
When you say 'footy', do you mean real footy or that bastardised yank version that we'd call rugby for poofs?
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I'm actually offended by this question. ;)

Ha, rugby for poofs! I like that one. I just call it hand egg, but I'm switching to rugby for poofs, you best believe! :D

Nah, when I say footy, I mean footy. As in football. As in fuck DAZN for their monopoly on EPL.

I don't have time for that rugby for poofs nonsense. Nor much of anything else. It's football for me, and the bit of rugby once in a while.

I don't even do hockey. Don't fuck with my Canuck status though....I own skates, skiis, a canoe, and go rough camping at least 2 weeks a year.




⚽⚽⚽⚽⚽⚽⚽⚽⚽⚽ don't get it twisted
 
codydion said:
gee, yknow alcohol is fairly euphoric for the first couple but after that the euphoria kinda dissipates and your left with inhibition. and boy can inhibition instigate some awesome memory's. as long as you don't over do it. to me that's is euphoria good times doing crazy sh*t with family and friends that you'll remember forever. or if you don't remember what happened somebody else will and you'll know you had fun.
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That's a fair assessment.
 
What is the therapeutic index for the ketone acetone when inhaled or orally ingested? My prediction is that acetone is more sedating than EtOH and easier to overdose on. I am aware that acetone was used as an anesthetic centuries ago, is produced in ketogenic diets, and also a metabolite of isopropanol when metabolized by the liver.
 
Acetone is indeed more toxic than ethanol, not by much though.

Rat LD50 oral acetone is 5.6g/kg
Rat LD50 oral ethanol is 6.6g/kg-7.0g/kg

I don't have any data right now on its anesthetic effects, but from memory, anesthetic effect correlates with logP (more fat soluble = stronger) so it would be logical to assume acetone is more potent as a sedative.

Clarke's says: Acetone is one of the solvents abused in ‘glue-sniffing’. Severe toxic effects have been associated with blood concentrations of 200 to 300 mg/L; a blood concentration of 550 mg/L has been reported in a fatality. The maximum permissible atmospheric concentration is 1000 ppm. Exposure to 1600 ppm for about 15 min causes irritation to the eyes and nose. Up to 20 mL has been ingested without ill-effect.

In any case, I cannot recommend anyone intentionally ingest acetone.
 
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sekio said:
Acetone is indeed more toxic than ethanol, not by much though.

Rat LD50 oral acetone is 5.6g/kg
Rat LD50 oral ethanol is 6.6g/kg-7.0g/kg

I don't have any data right now on its anesthetic effects, but from memory, anesthetic effect correlates with logP (more fat soluble = stronger) so it would be logical to assume acetone is more potent as a sedative.

Metabolite wise I would expect some to be breathed out and some metabolized to CO2 by way of acetic acid.

In any case, I cannot recommend anyone intentionally ingest acetone.
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Toxicity isn’t equivalent to overdose risk. If that was true then heroin wouldn’t be considered less toxic than ethanol or methamphetamine. And I mean if dosage is the only concern right now regarding ingestion if acetone then you can’t not recommend intentional ingestion any more than you can’t recommend ethanol.
 
Toxicity isn’t equivalent to overdose risk.
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I never said it was. Were you unfamiliar with the use of LD50 as a general rough marker of toxicity? Acetone has a narrower therapeutic index than ethanol too.

you can’t not recommend intentional ingestion any more than you can’t recommend ethanol.
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Nice double negative. I still don't recommend anyone drink acetone. (I don't recommend anyone drinks neat ethanol either, for what it's worth) It makes your breath stink, it lasts much longer than ethanol, and I presume it does nothing good to your liver or kidneys. (Though it is not mutagenic or teratogenic like acetaldehyde)

Here's a review of a case of acetone intoxication.
Another review focusing on the toxicology suggests that there is no intoxication up to 400 mg/L in blood - a level where ethanol is at least mildly intoxicating. (BAC of 0.04)
One more review.

The mere fact that acetone vapour would persist on one's breath, for a long time, and the requirement to consume a large amount to get intoxicated... not my cup of tea.
 
sekio said:
I never said it was. Were you unfamiliar with the use of LD50 as a general rough marker of toxicity? Acetone has a narrower therapeutic index than ethanol too.



Nice double negative. I still don't recommend anyone drink acetone. (I don't recommend anyone drinks neat ethanol either, for what it's worth) It makes your breath stink, it lasts much longer than ethanol, and I presume it does nothing good to your liver or kidneys. (Though it is not mutagenic or teratogenic like acetaldehyde)

Here's a review of a case of acetone intoxication.
Another review focusing on the toxicology suggests that there is no intoxication up to 400 mg/L in blood - a level where ethanol is at least mildly intoxicating. (BAC of 0.04)
One more review.

The mere fact that acetone vapour would persist on one's breath, for a long time, and the requirement to consume a large amount to get intoxicated... not my cup of tea.
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I just thought you meant toxicity as A general term to describe damage to internal organs. Acetone is dehydrating just like ethanol but I’m not aware of any toxicity especially acute toxicity of the hepatic or renal systems. If acetone is metabolized into arctic acid and co2 then I’d assume that hydration is a priority when ingesting this chemical. Yes I’m aware of ld50 however, I’m cautious when I see the rat ld50 because they have different dna than us humans (not that different but still pretty).
 
polymath said:
You'd have to inhale those acetone vapors for hours before you've accumulated enough in your blood to cause any intoxication. In more technical words, it has way too high blood-gas partition coefficient to be an inhalation anesthetic like diethyl ether.
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Yeah I figured that, however I remember reading about people inhaling vapors found in glue and I remember seeing someone saying that acetone is an active ingredient in the glue.
 
X11400 said:
Yeah I figured that, however I remember reading about people inhaling vapors found in glue and I remember seeing someone saying that acetone is an active ingredient in the glue.
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Also can you explain the “blood gas coefficient” to me in layman’s terms (make it still complex but easy for me to understand if you can).
 
X11400 said:
Also can you explain the “blood gas coefficient” to me in layman’s terms (make it still complex but easy for me to understand if you can).
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The glues that are capable of getting you intoxicated contain toluene, trichloroethane or other water-insoluble solvents. If it only contains acetone and ethyl or butyl acetate, it won't get you high.

The meaning of the blood-gas coefficient is that if the solvent is soluble in water/blood in large amounts, you have to accumulate a huge amount of it in your body before its concentration in the brain is enough to cause effects. That's also the reason why ethyl alcohol is taken as a drink and not by inhalation.
 
polymath said:
The glues that are capable of getting you intoxicated contain toluene, trichloroethane or other water-insoluble solvents. If it only contains acetone and ethyl or butyl acetate, it won't get you high.

The meaning of the blood-gas coefficient is that if the solvent is soluble in water/blood in large amounts, you have to accumulate a huge amount of it in your body before its concentration in the brain is enough to cause effects. That's also the reason why ethyl alcohol is taken as a drink and not by inhalation.
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I’m starting to properly interpret what you’re trying to say. I’m not 100% there yet, but I did try inhaling isopropanol and I felt only placebo intoxication sooner or later I just gave up because of the burning sensation in my lungs.
 
Honestly, i think if you dont know what toluene, trichloroethylene, or diethyl ether are you definitely should not be trying to get high off inhalents. And, i have tried they are very toxic especially toluene and trichloroethylene.

These drugs act somewhat like anesthetics . Imagine would you go to surgery where the anesthesiologist has only a rag or paper bag, no training, no equipment, nothing if you stop breathing, no way to monitor your vitals, and no idea what the chemicals even are.
 
d1nach said:
Honestly, i think if you dont know what toluene, trichloroethylene, or diethyl ether are you definitely should not be trying to get high off inhalents. And, i have tried they are very toxic especially toluene and trichloroethylene.

These drugs act somewhat like anesthetics . Imagine would you go to surgery where the anesthesiologist has only a rag or paper bag, no training, no equipment, nothing if you stop breathing, no way to monitor your vitals, and no idea what the chemicals even are.
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Yeah I know what toluene and diethyl ether are.
 
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