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Misc Alcohol as a CYP6D2 inducer - how does it work?

W

Wings of wax

Bluelighter
Joined
Oct 1, 2007
Messages
139
I am a Tramadol user, and there's a lot of speculation about how CYP6D2 converts the Tramadol into the wanted M1.

From what I understand, there are inhibitors, detractors and inducers of CYP6D2. We want to avoid the first two, but what about the inducers? Could it be advantageous to drink alcohol before or when on Tramadol, since ethanol is a CYP6D2 inducer?

Or is all of this just theoretical, without any real significance?

EDIT: It's CYP2D6. Sorry for the typo.
 
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Alcohol is a CYP2D6 inducer, I don't know to what extent. On my CYP450 chart, it's not listed as a strong inducer.

If I have a beer or glass of wine about 45 minutes before codeine though, I find that it can definitely help boost the high.
 
I remember asking this once and somebody told me that it was more down to liver Cirrhosis that causes dysfunctional inhibition & induction of certain enzymes, CYP2D6 being one of them.
Again, as Blonde said, I don't know to what extent this happens.
If it is true then you don't wanna go through Cirrhosis just to make this possible lol ;)

But it could also be so that it inhibits / induces enzymes regardless (without the "aid" of Cirrhosis).

One thing I'd like to add is that the potential for seizures may be increased. Though I'm totally not sure on that (sorry, it's early morning for me and my brain's not quite working) so I'd suggest researching into that :)
 
When I was first dabbling in opiates, I would sniff a bag of heroin a couple times a week. I remember one night I had been drinking, maybe a couple of beers.. anyway, I went to my friends dorm room and he gave me two tramadols and a little codeine syrup. At this time I was a lot more drug naive then I am now, and I really didn't know what either of these drugs were. Anyway, I took it, and about half an hour later I remember thinking, wow!! I feel like I'm on Heroin!

Then a few days later I tried taking three tramadols and I felt nothing, so alchohol definately does something.
 
monstanoodle said:
I remember asking this once and somebody told me that it was more down to liver Cirrhosis that causes dysfunctional inhibition & induction of certain enzymes, CYP2D6 being one of them.
Again, as Blonde said, I don't know to what extent this happens.
If it is true then you don't wanna go through Cirrhosis just to make this possible lol ;)

But it could also be so that it inhibits / induces enzymes regardless (without the "aid" of Cirrhosis).

One thing I'd like to add is that the potential for seizures may be increased. Though I'm totally not sure on that (sorry, it's early morning for me and my brain's not quite working) so I'd suggest researching into that :)
Click to expand...

Alcohol definitely is listed on my chart as a CYP2D6 inducer, interesting what you mention about cirrhosis though...
 
Yea I noted that it was on mine also (prolly the same one).
It'd be good to know, as you say, to what extent it does induce it.
When I had a small glass of wine before taking my CWE, it did seem to help so it's definitely possible that it does have a good enough effect to make a difference :)
 
It's probably due to all this new evidence that it's C6G (Codeine-6-Glucuronide) that accounts for more of the effects than Morphine does. It's fairly certain that this is true for the Analgesic effects, but as far as Euphoric effects are concerned, nothing is listed about C6G at all.
Infact that could be a task for the people on BL that are doing an excellent job on Wikipedia :) :

Find out as much as you possibly can about Codeine-6-Glucuronide and create a page on Wikipedia as best as you can ;)

I'd definitely say that Codeine feels different to Morphine in ways. So C6G must have a larger role of Physiological and Psychological effects than first assumed and anticipated.
 
I think this is simply misunderstanding.

Alcohol may induce 6d2 but it only strongly induces (with chronic use) 2E1.

Tramadol is metabolized by 2d6.

CYP450 6D2 =/= CYP450 2D6

...unless I am misunderstanding something, in which case I apologize. I don't know chemistry well.
 
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^ I don't know why you are talking about 6d2... did someone make a typo somewhere?

Alcohol does induce 2D6, it is listed on my chart. It's not a strong inducer though.

EDIT: Wait, I see, OP said CYP6D2... is that even an enzyme?
 
^in that case I think got blonde got it... even if alcohol is a 2D6 inducer, its only weakly so.
 
Mr Blonde said:
^ Just to sate my curiosity, how do you feel codeine to be different to morphine? More histamine reaction? What else? :)
Click to expand...

lol Histamine reaction ofcourse =D But there also seems to be an added "warmth" and "lightness" of the body and the high itself, though it's just as strong as Morphine in equivalent doses. Morphine seems to feel more "heavy".
It's difficult to put into words really.
 
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