Affinity for opiates receptors

[jasoncrest]

Among Buprenorphine, Naloxone and Naltrexone ,which one has the highest affinty for opiates receptors ?

If I shoot Suboxone, there will be a competition between the Bupe and Naloxone (both really want to go to the recptors) Which one will win?

 

[blahblahblahblah]

jason -

See my last post on this topic: injecting Suboxone

 

[jasoncrest]

jason -

See my last post on this topic: injecting Suboxone

Thanks. I replied to this post, but I didnt even read it....

So
1. If you take Bupe (Subutex) IV daily, switching to Suboxone IV won't put you in withdrawal?
2.If you don't take opiates, and decide to take Suboxone, the Bupe will bind to the receptors, but will some Naloxone also bind to the receptors?

 

[BilZ0r]

Which one will win depends on the concentration and the affinity.

If you get two drugs with affinities of X and Y... if you have them at the concentration X and Y 50% of the bound chemical will be X and 50% will be Y...

If you take Bupe (Subutex) IV daily, switching to Suboxone IV won't put you in withdrawal?

It should... to a degree... you know, partially. You're maximum opiate high will be less, if you get me.